Document Detail

Effect of diode laser on proliferation and differentiation of PC12 cells.
MedLine Citation:
PMID:  21701122     Owner:  NLM     Status:  In-Data-Review    
This study investigated the effects of diode (GaAlAs) laser irradiation at an effective energy density of 5 or 20 J/cm(2) on cell growth factor-induced differentiation and proliferation in pheochromocytoma cells (PC12 cells), and whether those effects were related to activation of the p38 pathway. Laser irradiation at 20 J/cm(2) significantly decreased the number of PC12 cells, while no difference was seen between the 5 J/cm(2) group and the control group (p<0.05). Western blotting revealed marked expression of neurofilament and β-tubulin, indicating greater neurite differentiation in the irradiation groups than in the control group at 48 hr. Irradiation also enhanced expression of phospho-p38. The decrease in number of cells after laser irradiation was accelerated by p38 inhibitor, while neurite differentiation was up-regulated by laser irradiation, even when the p38 pathway was blocked. This suggests that laser irradiation up-regulated neurite differentiation in PC12 cells involving p38 and another pathway.
Kensuke Saito; Sadamitsu Hashimoto; Han-Sung Jung; Masaki Shimono; Kan-Ichi Nakagawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Bulletin of Tokyo Dental College     Volume:  52     ISSN:  0040-8891     ISO Abbreviation:  Bull. Tokyo Dent. Coll.     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505414     Medline TA:  Bull Tokyo Dent Coll     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  D    
Department of Endodontics and Clinical Cariology, Tokyo Dental College.
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