Document Detail

Effect of dimethyl sulfoxide on the phase behavior of model stratum corneum lipid mixtures.
MedLine Citation:
PMID:  19559016     Owner:  NLM     Status:  MEDLINE    
Dimethyl sulfoxide (DMSO), an efficient transdermal enhancer, is proposed to alter the skin barrier by, at least partially, disturbing the lipid phase of the stratum corneum (SC). We have investigated, using differential scanning calorimetry and vibrational microspectroscopy, the effect of DMSO on the phase behavior of a lipid mixture formed by N-palmitoyl-d-erythro-sphingosine, deuterated palmitic acid, and cholesterol, mimicking the SC lipid phase. Our results reveal that DMSO favors the disordering of the lipid acyl chains. Moreover, the effect of DMSO is strongly concentration dependent and this dependence is reminiscent of that describing the DMSO transdermal enhancement. DMSO-induced fluidification affects primarily the fatty acid in the mixture. Therefore, it is proposed that the molecular mechanism of the transdermal transport enhancement caused by DMSO is associated with its H-bonding properties; its presence alters the interfacial H-bond network involving the fatty acid molecules and consequently the cohesive lipid packing.
Sungjong Kwak; Michel Lafleur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-24
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  161     ISSN:  1873-2941     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  11-21     Citation Subset:  IM    
Department of Chemistry, Center for Self-Assembled Chemical Systems, Université de Montréal, Montréal, Québec, H3C 3J7, Canada.
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MeSH Terms
Calorimetry, Differential Scanning
Cholesterol / chemistry
Dimethyl Sulfoxide / pharmacology*
Epidermis / chemistry*,  drug effects
Membranes, Artificial*
Palmitic Acid / chemistry
Phase Transition
Solvents / pharmacology*
Sphingosine / analogs & derivatives,  chemistry
Reg. No./Substance:
0/Membranes, Artificial; 0/Solvents; 0/erythro-(2R,3S)-sphingosine; 123-78-4/Sphingosine; 57-10-3/Palmitic Acid; 57-88-5/Cholesterol; 67-68-5/Dimethyl Sulfoxide

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