| Effect of diltiazem and metoprolol on left atrial appendix functions in patients with nonvalvular chronic atrial fibrillation. | |
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MedLine Citation:
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PMID: 17347074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Thrombo-embolic events are the important cause of mortality and morbidity in patients with chronic atrial fibrillation (CAF). The origin of thromboembolism is often the left atrial appendix (LAA). Flow rate velocity (FRV) inside the LAA is the major determinant of thrombus formation. The aim of our study was to investigate the effects of diltiazem and metoprolol used for ventricular rate control on FRV of the LAA in CAF patients and thus to evaluate the positive or negative effects of these two drugs on thromboembolic events. METHODS: Sixty-four patients were included in the study. All patients were suffering from CAF for more than a year. The patients were allocated to two groups according with agent used for rate control- metoprolol (Group 1; n=31) and diltiazem (Group 2; n=33). Transesophageal echocardiography was applied to all patients and LAA FRV was measured by a pulse wave Doppler in the 1/3 proximal portion of the LAA. The measurements were repeated after applying 5 mg metoprolol to Group 1 and 25 mg diltiazem to Group 2 via venous cannula. RESULTS: In Group 1 after metoprolol LAA flow velocity changed from 0.25 +/- 0.90 m/s to 0.25 +/- 0.10 m/s (p>0.05). In group 2 after diltiazem left atrial appendix FRV decreased from 0.21 +/- 0.9 m/s to 0.19 +/- 0.6 m/s (p>0.05). CONCLUSIONS: In patients with CAF metoprolol used for ventricular rate control had no effect on LAA flow velocity and the observed decrease in LAA flow rate velocity with intravenous diltiazem was insignificant. |
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Authors:
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Ilgin Karaca; Naci Coşkun; Mustafa Yavuzkir; Erdoğan Ilkay; Necati Dağli; Ahmet Işik; Mehmet Balin; Mehmet Akbulut; Nadi Arslan |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology Volume: 7 ISSN: 1302-8723 ISO Abbreviation: Anadolu Kardiyol Derg Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-09 Completed Date: 2007-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101095069 Medline TA: Anadolu Kardiyol Derg Country: Turkey |
Other Details:
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Languages: eng Pagination: 37-41 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Medical School, Firat University, Elaziğ, Turkey. ilgink@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage,
pharmacology,
therapeutic use Anti-Arrhythmia Agents / administration & dosage, pharmacology*, therapeutic use Atrial Appendage / drug effects*, physiology, ultrasonography Atrial Fibrillation / physiopathology*, ultrasonography Atrial Function, Left / drug effects* Blood Flow Velocity / drug effects Chronic Disease Diltiazem / administration & dosage, pharmacology*, therapeutic use Echocardiography, Transesophageal Female Humans Infusions, Intravenous Male Metoprolol / administration & dosage, pharmacology*, therapeutic use Middle Aged Thromboembolism / prevention & control Treatment Outcome Vasodilator Agents / administration & dosage, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Vasodilator Agents; 37350-58-6/Metoprolol; 42399-41-7/Diltiazem |
| Comments/Corrections | |
Comment In:
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Anadolu Kardiyol Derg. 2007 Mar;7(1):42-3
[PMID:
17347075
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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