Document Detail


Effect of diltiazem on lid tension during light-flash-induced eye blinks in the rabbit.
MedLine Citation:
PMID:  8440584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The purpose of this study was to examine the effect of the Ca blocker diltiazem in combination with the Ca chelator EGTA (ethyleneglycol-bis-ta-amino-ethyl ether]N,N'-tetraacetic acid) on eyelid tension generated during the light-induced eyeblink reflex in the adult rabbit. The goal is to develop nontoxic, nonsurgical therapies for blepharospasm. METHODS: Blinks were triggered in the alert rabbit, and tension was measured with a strain gauge attached to the eyelid. Strain gauge output was amplified, digitized, and stored on computer for later analysis. Experiments consisted of a set of trials in which identical light stimuli were delivered at 0.1 Hz for 5 min. RESULTS: In control trials, blink tensions decreased dramatically for the first seven to nine blinks and then levelled off, indicating that with respect to muscle tension output, blinks contained both rapidly habituating and nonhabituating components. After diltiazem and EGTA were injected in the lid, blinks were reduced 30% to 90% over those in control trials. Reductions could not be explained by injection trauma or irritation due to fluid volume, because injections of saline alone did not produce such tension depression. CONCLUSIONS: Diltiazem-EGTA produces a transient reduction in blink tension. A clinical application will depend on developing methods for the sustained release of these drugs in the eyelid.
Authors:
M Farbowitz; H Furst; R Kastner; N Patel; J Jacoby
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  34     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-29     Completed Date:  1993-03-29     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-304     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, New York University Medical Center, New York, New York 10016.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blinking / physiology*
Diltiazem / pharmacology*
Drug Combinations
Egtazic Acid / pharmacology
Electrophysiology
Eyelids / drug effects*,  physiology
Female
Male
Muscle Contraction / drug effects
Ocular Physiological Phenomena
Photic Stimulation
Rabbits
Grant Support
ID/Acronym/Agency:
EY-01297/EY/NEI NIH HHS; EY06232/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Drug Combinations; 42399-41-7/Diltiazem; 67-42-5/Egtazic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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