| Effect of a dihydropyridine-type calcium channel blocker on vascular remodeling after experimental balloon angioplasty. | |
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MedLine Citation:
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PMID: 21143146 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: Aim of the study was to evaluate the influence of the dihydropyridine derivative BW 9798 on intimal hyperplasia in a carotid artery injury model of New Zealand White rabbits on a high cholesterol diet. Methods: In carotid arteries of 50 New Zealand White rabbits atherosclerotic lesions were induced by cholesterol diet and electrostimulation of the artery. In 40 animals the resulting primary lesion was subjected to balloon angioplasty (BA). Three days prior to BA animals received BW 9798 or placebo per os until sacrifice three days or 28 days after BA. Results: BW 9798 lead to increased cross sectional area by 128.3% and an increased luminal area by 157% after 28 days after BA compared with placebo. However the degree of stenosis did not significantly decrease. The cell count of the different layers of the arteries decreased by 64.5% in the intima and by 62.6% compared with placebo treated animals after BA. Additionally the number of smooth muscle cell (SMC) layers in the neointima was significantly lower in BW 9798 treated animals than in placebo animals (8±3 vs 14±9, p<0.05) although the proliferation was not changed by BW 9798 treatment 3 days after BA. Conclusion: BW 9798 leads to significant changes in vessel wall geometry although the influence on vascular remodeling of this compound is unclear. It can be speculated that the compound affects the homeostasis of extracellular matrix, invasion of inflammatory cells into the vessel wall and the expression of cytokines. However, further investigation needs to clarify the role of BW 9798 on remodelling after BA. |
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Authors:
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Alexander F Kranzhöfer; Oliver Weingärtner; Martin Oberhoff; Karl R Karsch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular & hematological agents in medicinal chemistry Volume: 9 ISSN: 1875-6182 ISO Abbreviation: Cardiovasc Hematol Agents Med Chem Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101266881 Medline TA: Cardiovasc Hematol Agents Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Affiliation:
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Universitätsklinikum des Saarlandes, Klinik für innere Medizin III, Abteilung für Kardiologie, Angiologie und Internistische Intensivmedizin, Homburg/Saar, Germany. oweingartner@aol.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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