| Effect of digoxin on plasma clearance and anticoagulant effect of warfarin in rats. | |
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MedLine Citation:
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PMID: 6747809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The possible effects of digoxin on the elimination and anticoagulant action of warfarin were examined in rats. The pharmacokinetic parameters of warfarin after a single i.v. (1.2 mg/kg) or repeated oral coadministration with anticoagulant (0.6 mg/kg on day 1, thereafter 0.3 mg/kg) and digoxin (50 micrograms/kg) were not significantly different as compared with those in the group treated with warfarin alone. However, prothrombin complex activity (PCA) following coadministration with the diuretic was significantly and relatively rapidly recovered as compared with that in the warfarin group. The amounts of warfarin extracted by liver 2 and 6 h after a single i.v. dosing or 3 and 8 h after repeated oral dosing in the coadministered group were significantly decreased as compared with those in the group received warfarin alone. The renal function (renal plasma flow rate (RPF) and glomerular filtration rate) in the group coadministered with digoxin was significantly higher than that in the group receiving warfarin alone. On the other hand, the fraction of warfarin bound to BSA or rat plasma and the plasma water were little changed in the presence of digoxin. These results suggest that a pharmacological interaction, the decrease in the anticoagulant action, is induced between warfarin and digoxin coadministered. |
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Authors:
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T Ogiso; M Iwaki; Y Konishi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmacobio-dynamics Volume: 7 ISSN: 0386-846X ISO Abbreviation: J. Pharmacobio-dyn. Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-09-10 Completed Date: 1984-09-10 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7901854 Medline TA: J Pharmacobiodyn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 186-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminohippuric Acids
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blood Animals Blood Coagulation / drug effects* Digoxin / pharmacology* Drug Interactions Hematocrit Kinetics Liver / metabolism Male Protein Binding Proteins / metabolism Prothrombin / metabolism Rats Rats, Inbred Strains Thiosulfates / blood Warfarin / blood, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Aminohippuric Acids; 0/Proteins; 0/Thiosulfates; 20830-75-5/Digoxin; 7772-98-7/sodium thiosulfate; 81-81-2/Warfarin; 9001-26-7/Prothrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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