| Effect of digoxin on left ventricular contractility in newborns and infants estimated by echocardiography. | |
| | |
MedLine Citation:
|
PMID: 759184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In view of the known susceptibility of newborns to digoxin intoxication this study was undertaken in order to evaluate the effect of a relatively low digoxin dose on left ventricular contractility of newborn infants. Left ventricular ejection time, enddiastolic diameter and endsystolic diameter were measured by echocardiography before digitalization as well as between 2 and 4 h after the first digoxin dose (group 1 : 16 patients) or after full digitalization (group 2 : 12 patients). From these data, shortening fraction (SF) and mean velocity of fiber shortening (mean Vcf) were calculated. We found that SF and mean Vcf increased significantly in both groups after the first digoxin dose and after full digitalization. The increase was equal in newborns and infants. The mean plasma digoxin concentration after full digitalization was 2.2 ng/ml (range 0.7--4.4 ng/ml). These results demonstrate clearly the positive inotropic effect of a relatively low digoxin dose in newborns. |
| | |
Authors:
|
R Hofstetter; D Lang; G von Bernuth |
Related Documents
:
|
21668894 - Demographic consequences of increased winter births in a large aseasonally breeding mam... 21499444 - Prelinguistic vocal development in infants with typical hearing and infants with severe... 5947764 - Pneumoperitoneum in the newborn. 21912184 - Short-term outcome for term and near-term singleton infants with intrapartum polyhydram... 22515404 - Feasibility of implementing magnesium sulphate for neuroprotection in a tertiary obstet... 11194544 - Small-bowel perforation in very low birth weight neonates treated with high-dose dexame... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of cardiology Volume: 9 ISSN: 0301-4711 ISO Abbreviation: Eur J Cardiol Publication Date: 1979 Jan |
Date Detail:
|
Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404054 Medline TA: Eur J Cardiol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 1-11 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Cardiac Output / drug effects Child Digoxin / pharmacology*, therapeutic use Drug Administration Schedule Echocardiography Heart Failure / drug therapy* Humans Infant Infant, Newborn Myocardial Contraction / drug effects* Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
|
20830-75-5/Digoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Parachute mitral valve, coarctation of aorta, radius aplasia, and omphalocele in an infant with the ...
Next Document: His bundle block and concealed His bundle premature depolarization.