Document Detail

Effect of a digitalis drug on ventricular premature beats.
MedLine Citation:
PMID:  63914     Owner:  NLM     Status:  MEDLINE    
To determine the efficacy of digitalis drugs in suppressing ventricular ectopic activity, 142 patients with frequent (greater than 1 per minute) ventricular premature beats underwent acetyl strophanthidin tolerance testing. In 65 patients (46 per cent), frequency and grade were reduced during testing. In 37 (26 per cent), the ectopic activity remained unaltered; frequency increased during testing in the remaining 40 patients (28 per cent). In the group with a suppressive effect, ventricular premature beats decreased by 82 per cent, with complete abolition of arrhythmias in 46 per cent. The three groups were not distinguishable clinically by either the type or the extent of heart disease. The antiarrhythmic action of acetyl strophanthidin did not appear to depend upon its positive inotropic action. In some patients it appears to be due to an indirect reduction of Purkinje-fiber automaticity resulting from enhanced vagus-nerve activity that thereby lessens adrenergic tone on the heart.
B Lown; T B Graboys; P J Podrid; B H Cohen; M B Stockman; C E Gaughan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  296     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiac Complexes, Premature / drug therapy*
Drug Evaluation
Heart Rate / drug effects
Heart Ventricles
Middle Aged
Strophanthidin / administration & dosage,  analogs & derivatives*,  pharmacology
Reg. No./Substance:

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