| Effect of different penetration enhancers on diclofenac permeation across horse skin. | |
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MedLine Citation:
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PMID: 19815433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diclofenac is a hydrophilic non-steroidal anti-inflammatory drug widely used in humans and animals. Previous reports have shown that this compound has low percutaneous absorption in horses. The effect of five penetration enhancers (10% urea, 15% and 20% oleic acid and 5% and 10% d-limonene) on the percutaneous absorption of diclofenac diethylamine through horse skin was evaluated in vitro using Franz-type diffusion cells. All tested penetration enhancers induced a significant increase in diclofenac diethylamine permeation, with limonene showing the highest enhancing effect at the lowest concentration (5%) applied. The presence of the permeation enhancers did not affect lag-time. This is the first in vitro study of the effects of penetration enhancers on transdermal permeation of diclofenac diethylamine across horse skin. The results suggested that urea, limonene and 5% oleic acid were useful for enhancing the transdermal absorption of diclofenac diethylamine and may assist in the development of a transdermal formulation of diclofenac diethylamine for use in horses. |
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Authors:
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M Ferrante; A Andreeta; M F Landoni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-07 |
Journal Detail:
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Title: Veterinary journal (London, England : 1997) Volume: 186 ISSN: 1532-2971 ISO Abbreviation: Vet. J. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706281 Medline TA: Vet J Country: England |
Other Details:
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Languages: eng Pagination: 312-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2009. Published by Elsevier Ltd. |
Affiliation:
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Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, cc 296 (1900), La Plata, CONICET, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Animals Anti-Inflammatory Agents, Non-Steroidal / administration & dosage, pharmacokinetics* Cyclohexenes / pharmacology Diclofenac / administration & dosage, pharmacokinetics* Dose-Response Relationship, Drug Drug Synergism Horses / metabolism* Kinetics Male Oleic Acid / pharmacology Organ Culture Techniques Skin Absorption / drug effects* Terpenes / pharmacology Urea / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclohexenes; 0/Terpenes; 112-80-1/Oleic Acid; 138-86-3/limonene; 15307-86-5/Diclofenac; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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