Document Detail

Effect of different doses of chlorthalidone on blood pressure, serum potassium, and serum urate.
MedLine Citation:
PMID:  1089446     Owner:  NLM     Status:  MEDLINE    
Chlorthalidone given to 40 hypertensive women significantly decreased blood pressure and serum potassium levels and increased the serum urate concentration. There were no individual correlations between the reduction in blood pressure and the decrease in serum potassium or the increase in serum urate. A reduction in dosage from 50 mg daily to 50 mg three times a week produced no significant changes in the diastolic or mean blood pressures though the systolic blood pressure was moderately increased. Concomitantly, serum potassium increased and serum urate decreased significantly on the lower chlorthalidone dose. We conclude that high doses of oral diuretics compared with lower ones are of limited further benefit and may increase the risk of clinically significant hypokalaemia and hyperuricaemia.
C Bengtsson; G Johnsson; R Sannerstedt; L Werkö
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-05-05     Completed Date:  1975-05-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  197-9     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects*
Chlorthalidone / administration & dosage,  pharmacology*,  therapeutic use
Clinical Trials as Topic
Depression, Chemical
Hypertension / drug therapy
Potassium / blood*
Uric Acid / blood*
Reg. No./Substance:
0/Placebos; 69-93-2/Uric Acid; 7440-09-7/Potassium; 77-36-1/Chlorthalidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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