| Effect of different AV delays on left ventricular diastolic function and ANF levels in DDD paced hypertensive patients during daily activity and exercise. | |
| | |
MedLine Citation:
|
PMID: 10234717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fifteen hypertensive patients (13 men) with left ventricular hypertrophy, mean age 69 6 5 years, having complete heart block and paced in the DDD mode, were studied by two-dimensional and Doppler echo in 100 and 200 ms atrioventricular delays. ANF plasma levels were measured at rest and at peak exercise, during pacing with the two different atrioventricular delays. ANF plasma levels were significantly higher at pacing with long atrioventricular delays (200 ms), at rest (152.47 6 12.38 pg/mL vs 119 6 12.38 pg/mL, P, 0.001) and at exercise (180.93 6 11.51 vs 123.67 6 16.24 pg/mL, P, 0.0001). ANF plasma levels were significantly increased at exercise, compared to those at rest during pacing with the two different atrioventricular delays, but we found a more pronounced increase of ANF levels (from 152.47 6 10.49 pg/mL to 180.93 6 11.51 pg/mL), when the atrioventricular delays was set to 200 ms (P, 0.0001). A significant decrease of isovolumic relaxation time (from 123.33 6 20.5 to 105.33 6 11.06 ms, P, 0.001) was observed, during pacing with the short atrioventricular delays. Moreover, the peak early (E) to peak atrial (A) velocity ratio (E/A) was declined (from 0.89 6 0.7 to 0.57 6 0.18, P, 0.05). We also noticed that patients with small left ventricles exhibit greater increase in ANF plasma levels during DDD pacing with long atrioventricular delays (r 5 20.792, P 5 0.000). In conclusion, left ventricular diastolic function of our patients seems to be improved during DDD pacing with short (100 ms) atrioventricular delays, as it was expressed by echocardiographic and hormonal measurements. |
| | |
Authors:
|
F K Panou; N V Kafkas; N A Michelakakis; E P Matsakas; G B Dounis; N M Kouvousis; A S Perpinia; A A Zacharoulis |
Related Documents
:
|
3088297 - Sinus node function after selective elimination of sympathetic influences on the sinus ... 8594027 - Cardiovascular responses at the onset of static exercise in patients with dual-chamber ... 2476777 - The effect of an entrainment protocol on ouabain-induced ventricular tachycardia. 1568027 - Left ventricular performance at rest and during exercise in patients with dual-chamber ... 8088097 - The clinical use of upper extremity exercise. 3088297 - Sinus node function after selective elimination of sympathetic influences on the sinus ... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Pacing and clinical electrophysiology : PACE Volume: 22 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 1999 Apr |
Date Detail:
|
Created Date: 1999-06-18 Completed Date: 1999-06-18 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 635-42 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, General Hospital of Athens G Gennimatas, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Activities of Daily Living* Aged Atrial Natriuretic Factor / blood* Atrioventricular Node / physiopathology*, ultrasonography Cardiac Pacing, Artificial / methods* Cardiac Volume / physiology Diastole Echocardiography Echocardiography, Doppler Exercise Test Female Heart Block / complications, therapy, ultrasonography Humans Hypertension / complications* Hypertrophy, Left Ventricular / complications Male Middle Aged Myocardial Contraction / physiology Physical Exertion / physiology* Rest / physiology Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
|
85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electromagnetic interference of digital and analog cellular telephones with implantable cardioverter...
Next Document: What is the relationship of atrial flutter and fibrillation?