| Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. | |
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MedLine Citation:
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PMID: 10533866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diets containing genetically modified (GM) potatoes expressing the lectin Galanthus nivalis agglutinin (GNA) had variable effects on different parts of the rat gastrointestinal tract. Some effects, such as the proliferation of the gastric mucosa, were mainly due to the expression of the GNA transgene. However, other parts of the construct or the genetic transformation (or both) could also have contributed to the overall biological effects of the GNA-GM potatoes, particularly on the small intestine and caecum. |
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Authors:
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S W Ewen; A Pusztai |
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Publication Detail:
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Type: Comparative Study; Letter; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lancet Volume: 354 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-11-19 Completed Date: 1999-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1353-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cookery Diet Galanthus Gastric Mucosa / cytology, drug effects Genetic Engineering* Intestine, Small / drug effects*, metabolism Lectins / genetics, metabolism, pharmacology* Mannose-Binding Lectins* Plant Lectins Rats Solanum tuberosum / chemistry, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Lectins; 0/Mannose-Binding Lectins; 0/Plant Lectins; 0/snowdrop lectin |
| Comments/Corrections | |
Comment In:
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Lancet. 1999 Nov 13;354(9191):1726; author reply 1726-7
[PMID:
10568591
]
Lancet. 1999 Nov 13;354(9191):1725; author reply 1726-7 [PMID: 10568589 ] Lancet. 1999 Oct 16;354(9187):1314-5 [PMID: 10533853 ] Lancet. 1999 Oct 16;354(9187):1315-6 [PMID: 10533854 ] Lancet. 2001 Jan 27;357(9252):309-10 [PMID: 11214155 ] Lancet. 1999 Nov 13;354(9191):1728; author reply 1728-9 [PMID: 10568593 ] Lancet. 1999 Nov 13;354(9191):1725-6; author reply 1726-7 [PMID: 10568590 ] Lancet. 1999 Nov 13;354(9191):1729 [PMID: 10568596 ] Lancet. 1999 Nov 13;354(9191):1729 [PMID: 10568594 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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