Document Detail


Effect of diethylstilbestrol on reproductive function.
MedLine Citation:
PMID:  10428139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To review the effects of in utero exposure to diethylstilbestrol (DES) on müllerian development and subsequent reproductive function. DESIGN: The literature on DES and reproductive function was reviewed and summary data are presented. The studies were identified through the computerized MEDLINE database and a manual search of relevant bibliographies. RESULT(S): In utero exposure to DES resulted in reduced fertility and increased rates of ectopic pregnancy, spontaneous abortion, and preterm delivery. CONCLUSION(S): An understanding of the reproductive performance of women who were exposed to DES in utero is useful for counseling these patients regarding their risks and treatment options.
Authors:
J M Goldberg; T Falcone
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Fertility and sterility     Volume:  72     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-26     Completed Date:  1999-08-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Ohio 44195, USA. goldbej@cesmtp.ccf.org
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MeSH Terms
Descriptor/Qualifier:
Diethylstilbestrol / adverse effects*
Fallopian Tubes / abnormalities
Female
Genital Diseases, Female / chemically induced,  epidemiology,  therapy
Genitalia, Female / abnormalities
Humans
Mullerian Ducts / drug effects
Pregnancy
Pregnancy Complications / chemically induced,  epidemiology,  therapy
Pregnancy Rate
Prenatal Exposure Delayed Effects
Reproduction / drug effects*
Uterus / abnormalities
Chemical
Reg. No./Substance:
56-53-1/Diethylstilbestrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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