| Effect of dietary supplementation of astaxanthin from Phaffia rhodozyma on lipopolysaccharide-induced early inflammatory responses in male broiler chickens (Gallus gallus) fed a corn-enriched diet. | |
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MedLine Citation:
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PMID: 22111631 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Effect of dietary supplementation of astaxanthin (Ax) from Phaffia rhodozyma on lipopolysaccharide-induced inflammatory responses was investigated in male broiler chickens fed a corn-based diet. Birds (1 week of age) were fed a corn-enriched diet containing either 0 or 100 ppm Ax for 2 weeks and were intraperitoneally injected with lipopolysaccharide (LPS, 1 mg/kg body weight). Inflammatory responses were evaluated by determining changes in expression of messenger RNA (mRNA) in cytokines and mediators related to inflammatory responses (interleukin (IL)-1 beta and -6, inducible nitrite synthase (iNOS), interferon (IFN)- γ and cyclooxygenase (Cox)-2 in the liver and spleen after 2 h of LPS injection and plasma ceruloplasmin concentration as an acute phase protein. Birds fed Ax showed significantly higher iNOS mRNA expression in the liver and spleen compared to that of control birds. Ax-fed birds also showed greater increase in mRNA expression in the liver of IL-1, IL-6 and IFN-γ compared to that of control birds. The enhancing effect of Ax was further progressed when LPS was injected. No difference was found in plasma ceruloplasmin concentration between the Ax-fed group and control group. The results suggest that feeding supplementation of Ax (100 ppm) to a corn-enriched diet possibly does not have anti-inflammatory effect in male broiler chickens. |
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Authors:
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Kazuaki Takahashi; Tetsuya Takimoto; Kan Sato; Yukio Akiba |
Publication Detail:
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Type: Journal Article Date: 2011-07-13 |
Journal Detail:
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Title: Animal science journal = Nihon chikusan Gakkaihō Volume: 82 ISSN: 1740-0929 ISO Abbreviation: Anim. Sci. J. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956805 Medline TA: Anim Sci J Country: Australia |
Other Details:
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Languages: eng Pagination: 753-8 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Animal Science Journal © 2011 Japanese Society of Animal Science. |
Affiliation:
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Graduate School of Agricultural Science, Department of Animal Science, Tohoku University, Aoba, Sendai, Japan. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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