Document Detail

Effect of dietary starch, fat, and bicarbonate content on exercise responses and serum creatine kinase activity in equine recurrent exertional rhabdomyolysis.
MedLine Citation:
PMID:  14529137     Owner:  NLM     Status:  MEDLINE    
To determine the effect of dietary starch, bicarbonate, and fat content on metabolic responses and serum creatine kinase (CK) activity in exercising Thoroughbreds with recurrent exertional rhabdomyolysis (RER), 5 RER horses were fed 3 isocaloric diets (28.8 Mcal/d [120.5 MJ/d]) for 3 weeks in a crossover design and exercised for 30 minutes on a treadmill 5 days/wk. On the last day of each diet, an incremental standardized exercise test (SET) was performed. The starch diet contained 40% digestible energy (DE) as starch and 5% as fat: the bicarbonate-starch diet was identical but was supplemented with sodium bicarbonate (4.2% of the pellet): and the fat diet provided 7% DE as starch and 20% as fat. Serum CK activity before the SET was similar among the diets. Serum CK activity (log transformed) after submaximal exercise differed dramatically among the diets and was greatest on the bicarbonate-starch diet (6.51 +/- 1.5) and lowest on the fat diet (5.71 +/- 0.6). Appreciable differences were observed in the severity of RER among individual horses. Postexercise plasma pH, bicarbonate concentration, and lactate concentration did not differ among the diets. Resting heart rates before the SET were markedly lower on the fat diet than on the starch diet. Muscle lactate and glycogen concentrations before and after the SET did not differ markedly among the diets. A high-fat, low-starch diet results in dramatically lower postexercise CK activity in severely affected RER horses than does a low-fat, high-starch diet without measurably altering muscle lactate and glycogen concentrations. Dietary bicarbonate supplementation at the concentration administered in this study did not prevent increased serum CK activity on a high-starch diet.
Erica C McKenzie; Stephanie J Valberg; Sandra M Godden; Joe D Pagan; Jennifer M MacLeay; Ray J Geor; Gary P Carlson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  17     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-10-07     Completed Date:  2003-12-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  693-701     Citation Subset:  IM    
Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA.
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MeSH Terms
Animal Nutritional Physiological Phenomena
Creatine Kinase / blood
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Exercise Test / veterinary
Horse Diseases / blood,  metabolism*
Physical Conditioning, Animal*
Rhabdomyolysis / metabolism,  veterinary*
Sodium Bicarbonate / administration & dosage
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 144-55-8/Sodium Bicarbonate; EC Kinase

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