Document Detail


Effect of dietary selenite on development and intestinal absorption in offspring rats.
MedLine Citation:
PMID:  21062629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The present study aims to compare selenium (Se) status in offspring rats born to selenium-deficient and selenium supplemented dams and to analyse Se's influence on intestinal parameters and the intestinal absorption of selenomethionine (Se-Met).
MAIN METHODS: Male and female Wistar rats (150-200 g) were randomised in: control (C) (0.1 ppm Se), Se-deficient (SD) (0.01 ppm Se) and Se-supplemented (SS) (0.5 ppm Se) groups; and were mated to obtain their offspring. Se levels in serum, urine and faeces in offspring and in mothers' milk were measured by graphite-furnace atomic absorption spectrometry. Duodenal transport studies in offspring were performed using an in vivo perfusion of different Se-Met concentrations (2, 5, 10, 25, 75 and 150 μM).
KEY FINDING: A Se-deficient diet provoked a decrease in the offspring's body weight and intestinal parameters, while the supplemented diet increased these values. Serum Se levels were similar between Se-deficient and control offspring because the urinary excretion of Se was smaller to compensate for Se homeostasis. Intestinal Se-Met absorption obeys the Michaelis-Menten equation with lower apparent constant (K(m)) and maximal velocity (V(max)) in the SD group. However, the C and SS groups presented similar K(m) and different V(max). The V(max) showed greater values in the following order of rank: SS>C>SD groups.
SIGNIFICANCE: Selenium intake deficiencies in offspring lead to the development of compensatory mechanisms in order to normalise serum selenium levels. These mechanisms, however, do not permit normal body development; nor do they regulate intestinal parameters and Se-Met transport.
Authors:
M J Delgado; F Nogales; M L Ojeda; M L Murillo; O Carreras
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-06
Journal Detail:
Title:  Life sciences     Volume:  88     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-10     Completed Date:  2011-02-18     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  150-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Physiology and Zoology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Body Weight / drug effects
Dietary Supplements
Feces / chemistry
Female
Intestinal Absorption / drug effects*
Male
Maternal Nutritional Physiological Phenomena / physiology*
Rats
Rats, Wistar
Selenium / analysis,  blood,  pharmacology*,  urine
Selenomethionine / pharmacokinetics
Spectrophotometry, Atomic
Chemical
Reg. No./Substance:
1464-42-2/Selenomethionine; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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