| Effect of dietary salt restriction on urinary serotonin and 5-hydroxyindoleacetic acid excretion in man. | |
| | |
MedLine Citation:
|
PMID: 7510737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the effect of dietary salt restriction on urinary excretion of serotonin and its principal metabolite 5-hydroxyindoleacetic acid (5-HIAA) in man. DESIGN: We studied 16 healthy male volunteers (age range 20-28 years) who ate a standard diet containing 20 mmol/day NaCl, to which either 220 mmol/day NaCl or placebo was added as a supplement for 1 week each, according to a randomized, single-blind crossover design. METHODS: Urinary excretion of serotonin, 5-HIAA, noradrenaline and vanillylmandelic acid (VMA) were measured during the low- and high-salt periods using reverse-phase high-performance liquid chromatography. RESULTS: During the low-salt diet, 24-h urinary excretion of serotonin increased by 42%, accompanied by a 52% rise in the excretion of 5-HIAA. Salt restriction also increased noradrenaline excretion by 77% and VMA excretion by 40%. Regression analysis revealed a strong positive relationship between the excretion of serotonin and of noradrenaline (r = 0.84, P < 0.001) and between that of 5-HIAA and of VMA (r = 0.74, P < 0.001). CONCLUSIONS: Salt restriction stimulates the serotonergic system in man. Stimulation of this system, in conjunction with the sympathetic nervous system, may contribute to renal sodium conservation during dietary salt restriction in man. |
| | |
Authors:
|
A M Sharma; U Schorr; H M Thiede; A Distler |
Related Documents
:
|
7731157 - Acid-base balance in chronic peritoneal dialysis patients. 6801817 - Abnormal urinary excretion in sialoglycoconjugates in patients with mucopolysaccharidosis. 7058427 - Composition of urinary calculi collected in the durban area. 807197 - A biochemical study of the scarlet eye-color mutant of drosophila melanogaster. 2337977 - The preparation and some physical properties of ten methyl dithiastearate isomers. 16131527 - Human liver cholesteryl ester hydrolase: cloning, molecular characterization, and role ... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of hypertension Volume: 11 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1993 Dec |
Date Detail:
|
Created Date: 1994-04-15 Completed Date: 1994-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1381-6 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Universitätsklinikum Steglitz, Free University of Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Diet, Sodium-Restricted* Homeostasis / physiology Humans Hydroxyindoleacetic Acid / urine* Kidney / metabolism Male Natriuresis / physiology Norepinephrine / urine Serotonin / urine* Single-Blind Method Sodium / metabolism Sympathetic Nervous System / physiology Vanilmandelic Acid / urine |
| Chemical | |
Reg. No./Substance:
|
50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid; 55-10-7/Vanilmandelic Acid; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of nitric oxide synthesis increases blood pressure in healthy humans.
Next Document: Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymp...