Document Detail

Effect of dietary restriction with and without leucine supplementation on hepatic protein status in rats.
MedLine Citation:
PMID:  3169958     Owner:  NLM     Status:  MEDLINE    
In the present study effect of dietary restriction with and without leucine supplementation was observed on body and liver weights, and liver protein status, in adult rats. Animals were fed on two diets ad lib or were on 50 per cent and 25 per cent intakes. Dietary restriction resulted in loss of body and liver weights, hepatic protein, free-alpha-amino nitrogen and RNA contents and liver cell size (liver weight/DNA ratio). When compared with the control group, the decrease in these parameters was more in the dietary restricted leucine supplemented group. However, hepatic DNA content was not changed with the change in dietary regimen. The results suggest that leucine supplementation with dietary restriction may be more harmful for the animal than dietary restriction alone.
K Chugh; H Lal; V Shanker; A S Saini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  32     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    1988 Jan-Mar
Date Detail:
Created Date:  1988-11-21     Completed Date:  1988-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Department of Biochemistry, Medical College, Rohtak.
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MeSH Terms
Leucine / pharmacology*
Liver / metabolism*
Organ Size
Proteins / metabolism*
Reg. No./Substance:
0/Proteins; 61-90-5/Leucine

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