Document Detail


Effect of dietary restriction on total and bacterium-specific mucosal secretory immunoglobulin A in bile-diverted intestinal self-filling blind loops.
MedLine Citation:
PMID:  3338846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of starvation on the mucosal secretory immunoglobulin A (sIgA) response to bacterial antigens was studied in bile-free rat self-filling blind loops constructed at the end of a Roux-en-Y branch of jejunum. Rats were fed a 50% restricted diet for 1 to 4 weeks after surgery. sIgA was measured in the mucosa and lumen by an enzyme-linked immunosorbent assay. Dietary restriction caused a final rise of luminal sIgA which was less than 50% of that of normally fed controls Luminal bacteria counts were not different in the two groups. The percentage of total sIgA precipitated with intestinal bacteria was not significantly affected by dietary restriction, and there was no change in the specific binding of sIgA to several bacterial species. Nonprecipitated sIgA exhibited a low but significant specific binding to bacteria in both diet-restricted and fed rats. Diet restriction therefore reduced the total sIgA response to luminal bacteria, but the specific bacterial binding capacity per microgram of sIgA was not altered. In these short-term experiments diet-restricted animals appeared to be capable of secreting sIgA in excess of requirement, since the nonprecipitable luminal fraction contained free sIgA with binding capacity for bacteria. The ability of sIgA to react with specific antigens may therefore be of more significance as an indicator of bacterial susceptibility than the measurement of total sIgA.
Authors:
S N Lichtman; P M Sherman; G G Forstner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infection and immunity     Volume:  56     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-02     Completed Date:  1988-03-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Bacterial / immunology*,  metabolism
Antigens, Bacterial / immunology
Bile
Immunoglobulin A, Secretory / immunology*,  metabolism
Intestinal Mucosa / immunology
Intestines / immunology*,  microbiology
Male
Rats
Starvation / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial; 0/Immunoglobulin A, Secretory
Comments/Corrections

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