Document Detail

Effect of dietary polyunsaturated fatty acids on contractile function of hearts isolated from sedentary and trained rats.
MedLine Citation:
PMID:  10863956     Owner:  NLM     Status:  MEDLINE    
Moderate physical training induced a decrease in arterial blood pressure in fish oil-fed rats as compared to sunflower seed oil-fed rats. The purpose of this study was to determine if these changes were due to modifications of the left ventricular function of the heart. Forty rats were fed a semi-purified diet containing either 10% sunflower seed oil or 10% fish oil (EPAX 3000TG, Pronova). Each dietary group was assigned to two sub-groups, one being constituted by sedentary animals and the other by trained animals. Training was achieved by daily running for 60 minutes at moderate intensity for three weeks. At the end of the training period, the animals were sacrificed and their hearts were immediately perfused according to the working mode. The phospholipid fatty acid composition and parameters of the left ventricular function were determined. Feeding fish oil markedly reduced the proportion of n-6 polyunsaturated fatty acids (PUFA, 18:2 n-6, 20:4 n-6, 22:4 n-6 and 22:5 n-6) in cardiac phospholipids. The n-6 PUFA were replaced by n-3 PUFA (mainly docosahexaenoic acid). In sedentary animals, the fluid dynamic (aortic and coronary flow, cardiac output) was not modified by the diet. The heart rate was reduced (-10%) in n-3 PUFA-rich hearts. Physical training did not markedly alter the polyunsaturated fatty acid profile of cardiac phospholipids. Conversely, it reduced the heart rate, aortic flow and cardiac output (-11, -21 and -14%, respectively) at a similar extent in the two dietary groups. In a second set of experiments, the training period was repeated in animals fed a commercially available diet (A103, UAR) which simultaneously provided n-6 and n-3 fatty acids. In these dietary conditions, neither the aortic flow nor the heart rate was decreased by physical exercise. These results suggest that both n-6 and n-3 PUFA in the diet are necessary to ensure a good cardiac adaptation to moderate physical training. Furthermore, the fish oil-induced decrease in arterial blood pressure in trained animals was not related to changes in cardiac contractility, but to a decrease in vascular resistances. Moderate physical training + dietary n-3 PUFA might be used to prevent hypertension and cardiovascular diseases.
L Demaison; J Blet; J P Sergiel; S Gregoire; D Argaud
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, nutrition, development     Volume:  40     ISSN:  0926-5287     ISO Abbreviation:  Reprod. Nutr. Dev.     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-08-16     Completed Date:  2000-08-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8913069     Medline TA:  Reprod Nutr Dev     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  113-25     Citation Subset:  IM; S    
Unité de Nutrition Lipidique, INRA, BV 1540, Dijon, France.
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MeSH Terms
Blood Pressure
Cardiac Output
Dietary Fats, Unsaturated / administration & dosage,  pharmacology*
Fatty Acids / analysis
Fatty Acids, Omega-3 / pharmacology
Fatty Acids, Omega-6
Fatty Acids, Unsaturated / pharmacology
Fish Oils / administration & dosage,  pharmacology
Heart Rate
Myocardial Contraction / physiology*
Myocardium / chemistry
Phospholipids / analysis
Physical Conditioning, Animal
Physical Exertion*
Plant Oils / administration & dosage,  pharmacology
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Phospholipids; 0/Plant Oils; 8001-21-6/sunflower seed oil

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