| Effect of dietary patterns differing in carbohydrate and fat content on blood lipid and glucose profiles based on weight loss success of breast cancer survivors. | |
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MedLine Citation:
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PMID: 22225711 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT: INTRODUCTION: Healthy body weight is an important factor for prevention of breast cancer recurrence. Yet, weight loss and weight gain are not currently included in clinical practice guidelines for post treatment of breast cancer. The work reported addresses one of the questions that must be considered in recommending weight loss to patients: does it matter what diet plan is used, a question of particular importance since breast cancer treatment can increase risk for cardiovascular disease. METHODS: Women who completed treatment for breast cancer were enrolled in a non-randomized, controlled study investigating effects of weight loss achieved using two dietary patterns at the extremes of macronutrient composition, although both diet arms were equivalent in protein: high fat, low carbohydrate versus low fat, high carbohydrate. A non-intervention group served as the control arm; women were assigned to intervention arms based on dietary preferences. During the 6 month weight loss program, which was menu and recipe defined, participants had monthly clinical visits at which anthropometric data were collected and fasting blood was obtained for safety monitoring for plasma lipid profiles and fasting glucose. Results from 142 participants are reported. RESULTS: Adverse effects on fasting blood lipids or glucose were not observed in either dietary arm. A decrease in fasting glucose was observed with progressive weight loss and was greater in participants who lost more weight, but the effect was not statistically significant even though it was observed across both diet groups (P=0.21). Beneficial effects of weight loss on cholesterol (4.7%, P=0.001), triglycerides (21.8%, P=0.01), and LDL cholesterol (5.8%, P=0.06) were observed in both groups. For cholesterol (P=0.07) and LDL cholesterol (P=0.13), there tended to be greater reductions on the low fat diet pattern; whereas, for triglycerides (P=0.01) and HDL cholesterol (P=0.08), a decrease or increase, respectively, was greater on the low carbohydrate diet pattern. CONCLUSIONS: Since an individual's dietary preferences can impact dietary adherence and weight loss success, the lack of evidence of a negative effect of dietary pattern on biomarkers associated with cardiovascular risk is an important consideration in the development of breast cancer practice guidelines for physicians who recommend that their patients lose weight. Whether dietary pattern affects biomarkers that predict long term survival is a primary question in this ongoing clinical trial. |
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Authors:
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Henry J Thompson; Scot M Sedlacek; Devchand Paul; Pamela Wolfe; John N McGinley; Mary C Playdon; Elizabeth A Daeninck; Sara N Bartels; Mark R Wisthoff |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-6 |
Journal Detail:
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Title: Breast cancer research : BCR Volume: 14 ISSN: 1465-542X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100927353 Medline TA: Breast Cancer Res Country: - |
Other Details:
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Languages: ENG Pagination: R1 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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