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Effect of dietary nitrogen content on the urine metabolite profile of dairy cows assessed by NMR-based metabolomics.
MedLine Citation:
PMID:  22059599     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
NMR-based metabolomics was applied on urine samples from 32 cows that were fed on 4 levels of crude protein (124, 135, 151 and 166 g/kg DM, respectively) in a cross-over design with the aim of identifying urinary metabolites related to nitrogen intake and nitrogen efficiency. Principal component analysis (PCA) on selected regions of the obtained 1H NMR spectra revealed an effect of crude protein intake on NMR signals in the 0.5-3.0 ppm and 5.0-10.0 ppm regions. Partial least square (PLS) regressions confirmed a correlation between the NMR metabolite profile and both nitrogen intake and efficiency. The NMR signals that correlated with nitrogen intake and efficiency included urea, hippurate, phenylacetylglutamine/phenylacetylglycine and para-cresol sulphate, which all contributed to the prediction of nitrogen intake and efficiency. Thus, it was not possible to identify a single metabolite that could be used as a marker to predict nitrogen efficiency, and it can be concluded that a wide-ranging urinary metabolite profile is needed to evaluate nitrogen efficiency in ruminants.
Authors:
Hanne Christine Bertram; Christian C Yde; Xumin Zhang; Niels Bastian Kristensen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-8
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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