Document Detail


Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial.
MedLine Citation:
PMID:  23327487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test the hypothesis that dietary myo-inositol may improve insulin resistance and the development of gestational diabetes mellitus (GDM) in women at high risk of this disorder.
DESIGN: A prospective, randomized, double-blind, placebo controlled clinical trial, pilot study.
PARTICIPANTS: Non-obese singleton pregnant women with an elevated fasting glucose in the first or early second trimester were studied throughout pregnancy.
INTERVENTION: Supplementation with myo-inositol or placebo during pregnancy.
MAIN OUTCOME MEASURE: Development of GDM on a 75 g oral glucose tolerance test at 24-28 weeks' gestation. Secondary outcome measures were increased in BMI, need for maternal insulin therapy, macrosomia, polyhydramnios, neonatal birthweight and hypoglycemia.
RESULTS: Thirty-six women were allocated to receive myo-inositol and 39 placebo. The incidence of GDM in mid-pregnancy was significantly reduced (p = 0.001) in women randomized to receive myo-inositol compared to placebo (relative risk 0.127). Women randomized to receive myo-inositol also required less insulin therapy, delivered at a later gestational age, had significantly smaller babies with fewer episodes of neonatal hypoglycemia.
CONCLUSIONS: Myo-inositol supplementation in pregnancy reduced the incidence of GDM in women at high risk of this disorder. The reduction in incidence of GDM in the treatment arm was accompanied by improved outcomes.
Authors:
Barbara Matarrelli; Ester Vitacolonna; Matteo D'Angelo; Giulia Pavone; Peter A Mattei; Marco Liberati; Claudio Celentano
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2013-03-01
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  26     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-07     Completed Date:  2013-11-19     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  967-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Diabetes, Gestational / diet therapy,  epidemiology*,  prevention & control
Dietary Supplements
Double-Blind Method
Female
Fetus / drug effects*,  physiology
Glucose Tolerance Test
Humans
Incidence
Inositol / administration & dosage*
Insulin Resistance / physiology
Middle Aged
Pilot Projects
Placebos
Pregnancy
Young Adult
Chemical
Reg. No./Substance:
0/Placebos; 4L6452S749/Inositol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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