Document Detail

Effect of dietary linoleic acid content on the distribution of triacylglycerol molecular species in rat adipose tissue.
MedLine Citation:
PMID:  1487970     Owner:  NLM     Status:  MEDLINE    
The present study examined the effect of varying dietary linoleate intake (0.01, 0.24, 2.4, 24, 80 or 160 g/kg diet) for 24 weeks on the distribution of triacylglycerol (TG) molecular species in rat epididymal adipose tissue. Adipose TG fractions were purified by thin-layer chromatography and separated into different molecular species by reverse-phase high-performance liquid chromatography. The identification of TG species was based on fatty acid composition, retention time and the theoretical carbon number. When the dietary 18:2n-6 content was equal to or less than 24 g/kg, no significant amounts of n-6 fatty acids (mainly 18:2n-6) were observed in adipose tissue TG despite the fact that the levels of 20:4n-6 in liver phospholipids increased significantly. There were 12 major molecular species in adipose tissue when the dietary 18:2n-6 content was less than 2.4 g/kg. When the dietary 18:2n-6 content reached 24 g/kg, an additional six TG species containing one, two or three molecules of 18:2n-6 were observed. The levels of TG molecules containing two or three 18:2n-6 residues were further increased when the diet contained very large amounts of linoleic acid (160 g/kg). Conversely, those TG species containing only one 18:2n-6 residue became less abundant. It is suggested that the accumulation of these linoleate-rich TG molecular species in adipose tissue, particularly di- and trilinoleoyl containing TG, is the result of an adequate or an excessive intake of linoleic acid.
Y S Huang; X Lin; R S Smith; P R Redden; D K Jenkins; D F Horrobin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lipids     Volume:  27     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-02-19     Completed Date:  1993-02-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  711-5     Citation Subset:  IM    
Efamol Research Institute, Kentville, Nova Scotia, Canada.
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MeSH Terms
Adipose Tissue / drug effects*
Animals, Suckling
Dietary Fats / pharmacology*
Epididymis / chemistry
Fatty Acids / analysis*
Linoleic Acid
Linoleic Acids / pharmacology*
Liver / chemistry
Rats, Sprague-Dawley
Tissue Distribution
Triglycerides / chemistry*
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Linoleic Acids; 0/Triglycerides; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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