| Effect of dietary kelp on lipid peroxidation and glutathione peroxidase activity in livers of rats given breast carcinogen DMBA. | |
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MedLine Citation:
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PMID: 1907734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In our previous study of female rats, a diet containing 2% of powdered fronds of Laminaria religiosa (kelp) had a remarkable inhibitory effect on mammary tumorigenesis induced by orally given 7,12-dimethylbenz[a]anthracene (DMBA). In this study, the effect of the dietary kelp on lipid peroxidation and glutathione peroxidase (GSH-Px) activity in the liver was studied in the same experimental system. Two separate short- and long-term experiments were carried out on rats fed a diet with 2% kelp. DMBA (20 mg/kg body wt) was given to each animal 7 days after feeding began in short-term experiment and 27 days later in long-term experiment. Livers of all rats were obtained for quantitative determination and for histopathologic observation. Lipoperoxide in livers of the kelp-fed rats was of normal value, almost the same as that of untreated control rats; however, lipoperoxide in livers of control rats was significantly higher than in the other two groups in both experiments. A marked fatty change in livers of control rats was demonstrated in hepatic cells in peripheral zones of lobules in long-term experiment but not in short-term experiment. In long-term experiment, the amounts of GSH-Px and selenium in livers of kelp-fed rats were slightly less than those in untreated control rats but more than those in control rats. There was a more-intense positive reaction in the hepatic cells in the peripheral zones of the lobules in the kelp-fed and untreated rats and a less-intense positive reaction in control rats.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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H Maruyama; K Watanabe; I Yamamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition and cancer Volume: 15 ISSN: 0163-5581 ISO Abbreviation: Nutr Cancer Publication Date: 1991 |
Date Detail:
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Created Date: 1991-09-09 Completed Date: 1991-09-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 221-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Kitasato University School of Hygienic Sciences, Kanagawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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9,10-Dimethyl-1,2-benzanthracene
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administration & dosage,
toxicity* Administration, Oral Animals Antineoplastic Agents / pharmacology Diet* Female Glutathione Peroxidase / metabolism* Immunohistochemistry Lipid Peroxidation / drug effects* Lipid Peroxides / metabolism Liver / chemistry, drug effects, metabolism* Mammary Neoplasms, Experimental / chemically induced, prevention & control Rats Rats, Inbred Strains Seaweed / physiology* Selenium / analysis, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Lipid Peroxides; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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