Document Detail

Effect of a dietary intervention and n-3 fatty acid supplementation on measures of serum lipid and insulin sensitivity in persons with HIV.
MedLine Citation:
PMID:  19846544     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Elevated serum triglyceride and low HDL-cholesterol concentrations have been reported in persons with HIV.
OBJECTIVE: The effect of a dietary intervention plus n-3 (omega-3) fatty acid supplementation on serum triglycerides and markers of insulin sensitivity was investigated.
DESIGN: Fifty-four persons with HIV and elevated serum triglycerides (>150 mg/dL) and/or abnormal Quantitative Insulin Sensitivity Check Index values (<0.35 but >0.30) were recruited for a dietary intervention in which total fat, type of fat, fiber, and glycemic load were controlled along with supplementation with n-3 fatty acids to achieve an intake of 6 g/d. The subjects were randomly assigned to an intervention or control group, and serum lipids, markers of insulin sensitivity, and serum phospholipid fatty acids were measured in both groups at baseline, 3 wk, and 13 wk.
RESULTS: Triglycerides in the intervention group decreased from a median of 180 mg/dL (interquartile range: 141, 396) to 114 mg/dL (interquartile range: 84, 169) from baseline to 3 wk, whereas they remained stable in the control group (P = 0.003). Serum phospholipid fatty acids indicated a decrease in de novo lipogenesis and a decrease in arachidonic acid (% nmol; P <or= 0.001) in the intervention group. At 3 wk, the insulin area under the curve decreased but not significantly.
CONCLUSIONS: Diet and n-3 fatty acid supplementation dramatically reduced serum triglycerides, decreased arachidonic acid in the phospholipids fraction, and appeared to decrease the de novo lipogenesis associated with the metabolic syndrome in the intervention group.
Margo N Woods; Christine A Wanke; Pei-Ra Ling; Kristy M Hendricks; Alice M Tang; Tamsin A Knox; Charlotte E Andersson; Kimberly R Dong; Sally C Skinner; Bruce R Bistrian
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2009-10-21
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2009-12-08     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1566-78     Citation Subset:  AIM; IM    
Department of Public Health and Community Medicine, Nutrition/Infection Unit, Tufts University School of Medicine, Boston, MA, USA.
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MeSH Terms
Arachidonic Acid / blood
Area Under Curve
Body Mass Index
Cholesterol, HDL / blood
Dietary Supplements
Fatty Acids, Omega-3 / administration & dosage*
HIV Infections / metabolism*
Insulin Resistance
Middle Aged
Phospholipids / blood
Triglycerides / blood*
Grant Support
M01-RR00054/RR/NCRR NIH HHS; P01-D45734//PHS HHS; P30 DA013868/DA/NIDA NIH HHS; R01 DK63619/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Cholesterol, HDL; 0/Fatty Acids, Omega-3; 0/Phospholipids; 0/Triglycerides; 506-32-1/Arachidonic Acid

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