Document Detail

Effect of dietary fish oil on fecal bile acid and neutral sterol excretion in healthy volunteers.
MedLine Citation:
PMID:  9558749     Owner:  NLM     Status:  MEDLINE    
Diet-induced increases in fecal excretion of secondary bile acids (deoxy- and lithocholic acid) and certain neutral sterols (4-cholesten-3-one and 5a-cholestan-3-one) play a role in colon cancer development, whereas dietary fish oil (FO) has been implicated as a protective agent. In the present study the effects of FO and corn oil (CO) on these fecal parameters were investigated in 12 healthy volunteers consuming a low fat (30% of energy) controlled basal diet. After 4 weeks of FO supplementation (4.4 g omega-3 fatty acids/day), daily excretion of lithocholic acid showed a trend to lower values compared to CO consumption (p = 0.2), whereas other bile acids were not different during both study periods. Daily excretion of the putative colon carcinogen 4-cholesten-3-one was significantly lower in the FO compared to the CO period. This may be another biochemical mechanism by which FO exerts its protective effect on colon cancer development.
H P Bartram; A Gostner; E Kelber; G Dusel; W Scheppach; H Kasper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zeitschrift für Ernährungswissenschaft     Volume:  37 Suppl 1     ISSN:  0044-264X     ISO Abbreviation:  Z Ernahrungswiss     Publication Date:  1998  
Date Detail:
Created Date:  1998-05-21     Completed Date:  1998-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413632     Medline TA:  Z Ernahrungswiss     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  139-41     Citation Subset:  IM    
Department of Medicine, University of Würzburg.
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MeSH Terms
Bile Acids and Salts / analysis,  metabolism*
Dietary Fats, Unsaturated*
Feces / chemistry*
Fish Oils*
Reference Values
Sterols / analysis,  metabolism*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dietary Fats, Unsaturated; 0/Fish Oils; 0/Sterols

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