Document Detail

Effect of dietary fats and proteins on drug metabolism.
MedLine Citation:
PMID:  3559913     Owner:  NLM     Status:  MEDLINE    
Rats were given diets ad libitum which varied in the amount (5 or 15%) and kind of fat [coconut oil (CNO) vs corn oil (CO)]. Animals were injected either with hexobarbital or pentobarbital and sleeping time was recorded. With animals eating a low fat diet, there were slight differences between the CNO vs CO groups. At the higher fat level, animals receiving the polyunsaturated diet slept more than twice as long as compared to animals eating a diet with saturated oil. Simultaneous injection with carbon tetrachloride significantly increased the sleeping time between the two dietary fat groups. Also, the kind of protein and level of fat in the diet had an influence on sleeping times. It was concluded that both the quality and quantity of fat as well as the quality of the protein can influence drug metabolism.
J J Kabara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer     Volume:  7     ISSN:  0731-8898     ISO Abbreviation:  J. Environ. Pathol. Toxicol. Oncol.     Publication Date:    1987 Jan-Feb
Date Detail:
Created Date:  1987-05-18     Completed Date:  1987-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501420     Medline TA:  J Environ Pathol Toxicol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
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MeSH Terms
Carbon Tetrachloride / metabolism,  pharmacology
Corn Oil / administration & dosage
Dietary Fats / administration & dosage*
Dietary Proteins / administration & dosage*
Hexobarbital / metabolism,  pharmacology
Lipids / blood
Pentobarbital / metabolism,  pharmacology
Pharmaceutical Preparations / metabolism*
Plant Oils*
Sleep / drug effects
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Proteins; 0/Lipids; 0/Pharmaceutical Preparations; 0/Plant Oils; 56-23-5/Carbon Tetrachloride; 56-29-1/Hexobarbital; 76-74-4/Pentobarbital; 8001-30-7/Corn Oil; 8001-31-8/coconut oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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