Document Detail

Effect of dietary fat on the small intestinal mucosa.
MedLine Citation:
PMID:  2806993     Owner:  NLM     Status:  MEDLINE    
The presence of food within the small intestinal lumen promotes mucosal cell proliferation. To define the trophic role of triglycerides, three groups of eight female Wistar rats were isocalorically fed for four weeks with either Vivonex, or Vivonex with 50% calorie substitution with an essential fatty acid mixture, or Vivonex with 50% calorie substitution with a saturated fatty acid mixture. Although Vivonex caused greater body weight gain, both essential fatty acids and saturated fatty acids increased small intestinal weight, mucosal weight, protein and DNA overall, and in each of three intestinal segments (proximal, middle and distal), compared with Vivonex. Mucosal indices were similar for essential fatty acids and saturated fatty acids. These results show that triglycerides, regardless of essential fatty acid content, are trophic to the rat small intestinal mucosa.
D G Maxton; E U Cynk; A P Jenkins; R P Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  30     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-12-04     Completed Date:  1989-12-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1252-5     Citation Subset:  AIM; IM    
Gastrointestinal Laboratory, Rayne Institute, St Thomas' Hospital, London.
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MeSH Terms
DNA / analysis
Dietary Fats / pharmacology*
Dietary Fats, Unsaturated / pharmacology
Fatty Acids, Essential / pharmacology
Food Additives / pharmacology
Intestinal Mucosa / analysis,  anatomy & histology,  drug effects*
Intestine, Small / analysis,  anatomy & histology,  drug effects*
Organ Size
Organic Chemicals
Rats, Inbred Strains
Weight Gain
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Essential; 0/Food Additives; 0/Organic Chemicals; 9007-49-2/DNA; 93197-02-5/Vivonex

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