Document Detail

Effect of dietary fat content on oral bioavailability of menatetrenone in humans.
MedLine Citation:
PMID:  8877895     Owner:  NLM     Status:  MEDLINE    
The purpose of this investigation was to determine the effects of fat content and frequency of meals on the oral bioavailability of menatetrenone (2-methyl-3-all-trans-tetraprenyl-1,4-naphthoquinone), a vitamin K2 with four isoprene units. In the first series of studies, menatetrenone (15 mg) was administered at breakfast time to 18 healthy male volunteers after meals with three different fat contents (meals A, B, and C) on three occasions in a crossover design. The three types of meals had almost the same calorie content (721-746 kcal) with varied fat contents (A, 8.8 g; B, 20.0 g; C, 34.9 g). The area under the plasma menatetrenone concentration-time curve within the first 24 h (AUC0-24) increased with increase of fat content: 371 +/- 194, 485 +/- 150, and 1024 +/- 341 ng.h/mL (mean +/- SD, n = 18) after meals A, B, and C, respectively. On the fourth occasion, the same dose of menatetrenone was administered to all volunteers after taking meal B, but in this case the lunch 5 h after drug administration was omitted from the protocol. The time profile of plasma menatetrenone showed a single peak when lunch was not taken, whereas it showed two peaks with lunch. On the fifth occasion, 12 out of 18 volunteers took the same dose of menatetrenone after a meal with the highest fat content (53.8 g of fat and 789 kcal; meal D), showing that AUC0-24 was almost the same as that for meal C, 1027 +/- 389 and 991 +/- 392 ng.h/mL (n = 12) for meals C and D, respectively. The oral bioavailability of lipid-soluble vitamin K was influenced by the fat content of a meal, although the increase in bioavailability seemed to reach a peak when the lipid content of the meal was > 35 g.
T Uematsu; S Nagashima; M Niwa; K Kohno; T Sassa; M Ishii; Y Tomono; C Yamato; M Kanamaru
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  85     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-09     Completed Date:  1997-01-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1012-6     Citation Subset:  IM    
Department of Pharmacology, Gifu University School of Medicine, Japan.
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MeSH Terms
Administration, Oral
Biological Availability
Dietary Fats / administration & dosage*
Middle Aged
Vitamin K / analogs & derivatives*,  pharmacokinetics
Vitamin K 2 / analogs & derivatives
Reg. No./Substance:
0/Dietary Fats; 11032-49-8/Vitamin K 2; 12001-79-5/Vitamin K; 863-61-6/menatetrenone

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