| Effect of dietary cholesterol and taurocholate on cholesterol 7 alpha-hydroxylase and hepatic LDL receptors in inbred mice. | |
| | |
MedLine Citation:
|
PMID: 8354958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Compared to BALB/c mice, inbred C57BL/6 mice are more susceptible to developing fatty streak atherosclerotic lesions when fed a cholesterol-rich diet containing taurocholate. We examined the metabolic basis for the taurocholate requirement. In contrast to widely accepted assumptions, taurocholate did not increase cholesterol absorption in either strain of mouse. However, in susceptible C57BL/6 mice, taurocholate was required to increase plasma concentrations of apoB. In both strains, the cholesterol-rich diet increased both the activity and mRNA for 7 alpha-hydroxylase, a compensatory response to maintain cholesterol homeostasis. In both strains, adding taurocholate to the diet suppressed both the activity and mRNA for 7 alpha-hydroxylase, thus blocking this important compensatory response. The cholesterol-rich diet (without taurocholate) significantly increased hepatic cholesterol content in both strains of mice, but repressed low density lipoprotein (LDL) receptor mRNA only in BALB/c mice (not in C57BL/6 mice). However, adding taurocholate to the cholesterol-rich diet did decrease LDL receptor mRNA in C57BL/6 mice. In C57BL/6, but not in BALB/c mice, there was a linear parallel relationship between 7 alpha-hydroxylase mRNA and LDL receptor mRNA. These data show the existence of strain-specific differences in the effects of dietary cholesterol and taurocholate on 7 alpha-hydroxylase and LDL receptor expression. The combined data suggest that genetic factors determine how the expression of hepatic LDL receptors responds to dietary cholesterol and taurocholate. |
| | |
Authors:
|
S Dueland; J Drisko; L Graf; D Machleder; A J Lusis; R A Davis |
Related Documents
:
|
8348338 - Differential effects of ne, clon, and 5-ht on feeding and macronutrient selection in ge... 19028458 - Four weeks high fat feeding induces insulin resistance without affecting dopamine relea... 19932868 - Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygou... 19324038 - Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apoli... 3432188 - Effects of feeding deoxynivalenol (don, vomitoxin)-contaminated wheat to female white l... 8580578 - Effect of lipid emulsions for total parenteral nutrition on regeneration of the liver a... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of lipid research Volume: 34 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 1993 Jun |
Date Detail:
|
Created Date: 1993-09-21 Completed Date: 1993-09-21 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 923-31 Citation Subset: IM |
Affiliation:
|
Atherosclerosis Research Center, University of Colorado Health Sciences Center, Denver 80262. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apolipoproteins B / blood Bile / metabolism Cholesterol 7-alpha-Hydroxylase / metabolism* Cholesterol, Dietary / pharmacokinetics, pharmacology* Diet Female Intestinal Absorption / physiology Liver / metabolism* Mice Mice, Inbred BALB C Mice, Inbred C57BL Receptors, LDL / metabolism* Species Specificity Taurocholic Acid / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
DK-34914/DK/NIDDK NIH HHS; HL-37195/HL/NHLBI NIH HHS; HL-42488/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins B; 0/Cholesterol, Dietary; 0/Receptors, LDL; 81-24-3/Taurocholic Acid; EC 1.14.13.17/Cholesterol 7-alpha-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolism and choleretic activity of homochenodeoxycholic acid in the hamster.
Next Document: Dietary cholesterol stimulates hepatic biosynthesis of triglyceride and reduces oxidation of fatty a...