Document Detail

Effect of dietary cholesterol and fat on cell cholesterol transfer to postprandial plasma in hyperlipidemic men.
MedLine Citation:
PMID:  17680290     Owner:  NLM     Status:  MEDLINE    
Postprandial chylomicrons are potent ultimate acceptors of cell membrane cholesterol and are believed to accelerate reverse cholesterol transport (RCT). We compared the effects of meals rich in polyunsaturated fat (PUFA) and either high (605 mg) or low (151 mg) in cholesterol and a meal rich in dairy fat (DF) in the form of cream on net in vitro transport of red blood cell (RBC) membrane cholesterol to 4 and 6 h postprandial plasma in eight normotriglyceridemic (NTG-H) and eight hypertriglyceridemic (HTG-H) men with mild to moderate hypercholesterolemia. In HTG-H men, cell cholesterol accumulation in 6-h postprandial plasma was significantly (P = 0.02) less after the PUFA-HC meal compared with the other meals. The significant (P < 0.001) increase in cell plus endogenous cholesterol accumulation in the triglyceride-rich lipoprotein (TRL) fraction of 4 h postprandial plasma incubated with RBC was significantly (P = 0.007) higher after the PUFA-HC meal compared with DF meal in HTG-H men. In NTG-H men, cholesterol accumulation in plasma and plasma lipoproteins in the presence and absence of RBC was not significantly affected by the type of meal ingested. These data suggest that addition of large amounts of cholesterol to a PUFA meal may impair diffusion-mediated transport of cell membrane cholesterol to postprandial plasma and that replacing DF with PUFA in a meal increases postprandial lipemia and may potentially increase cholesterol accumulation in atherogenic postprandial TRL in HTG-H men.
Wayne H F Sutherland; Sylvia A de Jong; Robert J Walker
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-08-07
Journal Detail:
Title:  Lipids     Volume:  42     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2008-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  901-11     Citation Subset:  IM    
Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin 9054, New Zealand.
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MeSH Terms
Cholesterol / blood*,  metabolism
Cholesterol, Dietary / administration & dosage,  pharmacology*
Fatty Acids, Unsaturated / administration & dosage,  pharmacology*
Hypercholesterolemia / blood*
Hypertriglyceridemia / blood*
Lipoproteins / blood,  metabolism
Postprandial Period / physiology*
Time Factors
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 57-88-5/Cholesterol

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