Document Detail


Effect of dietary cholesterol and fat on cell cholesterol transfer to postprandial plasma in hyperlipidemic men.
MedLine Citation:
PMID:  17680290     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postprandial chylomicrons are potent ultimate acceptors of cell membrane cholesterol and are believed to accelerate reverse cholesterol transport (RCT). We compared the effects of meals rich in polyunsaturated fat (PUFA) and either high (605 mg) or low (151 mg) in cholesterol and a meal rich in dairy fat (DF) in the form of cream on net in vitro transport of red blood cell (RBC) membrane cholesterol to 4 and 6 h postprandial plasma in eight normotriglyceridemic (NTG-H) and eight hypertriglyceridemic (HTG-H) men with mild to moderate hypercholesterolemia. In HTG-H men, cell cholesterol accumulation in 6-h postprandial plasma was significantly (P = 0.02) less after the PUFA-HC meal compared with the other meals. The significant (P < 0.001) increase in cell plus endogenous cholesterol accumulation in the triglyceride-rich lipoprotein (TRL) fraction of 4 h postprandial plasma incubated with RBC was significantly (P = 0.007) higher after the PUFA-HC meal compared with DF meal in HTG-H men. In NTG-H men, cholesterol accumulation in plasma and plasma lipoproteins in the presence and absence of RBC was not significantly affected by the type of meal ingested. These data suggest that addition of large amounts of cholesterol to a PUFA meal may impair diffusion-mediated transport of cell membrane cholesterol to postprandial plasma and that replacing DF with PUFA in a meal increases postprandial lipemia and may potentially increase cholesterol accumulation in atherogenic postprandial TRL in HTG-H men.
Authors:
Wayne H F Sutherland; Sylvia A de Jong; Robert J Walker
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-08-07
Journal Detail:
Title:  Lipids     Volume:  42     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-19     Completed Date:  2008-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  901-11     Citation Subset:  IM    
Affiliation:
Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin 9054, New Zealand. wayne.sutherland@stonebow.otago.ac.nz
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cholesterol / blood*,  metabolism
Cholesterol, Dietary / administration & dosage,  pharmacology*
Fatty Acids, Unsaturated / administration & dosage,  pharmacology*
Humans
Hypercholesterolemia / blood*
Hypertriglyceridemia / blood*
Lipoproteins / blood,  metabolism
Male
Postprandial Period / physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Fatty Acids, Unsaturated; 0/Lipoproteins; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical and multifocal-electroretinographic findings of congenital tilted disc syndrome associated ...
Next Document:  Dietary virgin olive oil reduces oxidative stress and cellular damage in rat brain slices subjected ...