| Effect of dietary astaxanthin at different stages of mammary tumor initiation in BALB/c mice. | |
| | |
MedLine Citation:
|
PMID: 20651366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of astaxanthin on tumor growth, cardiac function and immune response in mice were studied. Female BALB/c mice were fed a control diet (diet C) for 8 weeks, 0.005% astaxathin for 8 weeks (diet A), or diet C for weeks 1-5 followed by diet A thereafter (diet CA). Mice were injected with a mammary tumor cell line on day 7 and tumor growth was measured daily. Mice fed diet A had extended tumor latency and lower tumor volume (p<0.05). Interestingly, those fed diet CA showed the fastest tumor growth. Astaxanthin feeding elevated plasma astaxanthin concentrations; there was no difference in plasma astaxanthin between mice fed CA and those fed A. Mice fed diet A, but not CA, had a higher (p<0.05) natural killer cell subpopulation and plasma interferon-gamma concentration compared to those fed diet C. Astaxanthin delayed tumor growth and modulated immune response, but only when astaxanthin was given before tumor initiation. This suggests that an adequate blood astaxanthin status is needed to protect against tumor initiation; conversely, astaxanthin supplementation after tumor initiation may be contraindicated. |
| | |
Authors:
|
Ruriko Nakao; O Lynne Nelson; Jean Soon Park; Bridget D Mathison; Pam A Thompson; Boon P Chew |
Related Documents
:
|
3023996 - Nuclear damage of colon epithelial cells by the food carcinogen 2-amino-3-methylimidazo... 3133106 - Inhibition of mammary carcinogenesis in rats by dietary restriction. 1255776 - Effect of leupeptin, a protease inhibitor, on induction of bladder tumors in rats by n-... 20839056 - In vitro colonic fermentation and glycemic response of different kinds of unripe banana... 9316236 - Performance of west african dwarf goats fed dehydrated poultry manure as a dry season s... 1746026 - Cadmium accumulation and metallothionein concentrations after 4-week dietary exposure t... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-07-23 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
|
Languages: eng Pagination: 2171-5 Citation Subset: IM |
Affiliation:
|
School of Food Science, Washington State University, Pullman, WA 99164, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Female Glutathione / metabolism Interferon-gamma / biosynthesis Mammary Neoplasms, Experimental / immunology, pathology, prevention & control* Mice Mice, Inbred BALB C Neoplasm Staging Serum Amyloid A Protein / analysis Tumor Necrosis Factor-alpha / blood Ventricular Function, Left Xanthophylls / administration & dosage |
| Chemical | |
Reg. No./Substance:
|
0/Serum Amyloid A Protein; 0/Tumor Necrosis Factor-alpha; 0/Xanthophylls; 472-61-7/astaxanthine; 70-18-8/Glutathione; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Liver Regeneration and its Impact on Post-hepatectomy Metastatic Tumour Recurrence.
Next Document: Biodistribution of two octreotate analogs radiolabeled with indium and yttrium in rats.