Document Detail

Effect of dietary antioxidant trace element supply on cardiac tolerance to ischemia-reperfusion in the rat.
MedLine Citation:
PMID:  8576945     Owner:  NLM     Status:  MEDLINE    
Over a 10-week period, female Wistar rats received a diet containing various levels of four trace elements (Zn, Cu, Mn, Se), co-factors of antioxidant enzymes (superoxide dismutase SOD, glutathione peroxidase GPx), in order to examine the influence of supplementation or deficiency of these elements (i) on tissue antioxidant enzyme defence systems, and (ii) on the susceptibility of the myocardium to ischemia-reperfusion injury. At the end of the dietary treatment, hearts were perfused at constant flow (11 ml/min) before being subjected to 15 min of total global normothermic ischemia, followed by reperfusion. The effects of the various diets (deficient, standard or supplemented) were estimated by studying functional recovery of various cardiac parameters (left ventricular developed pressure LVDP, dP/dtmax, heart rate x LVDP) as well as ultrastructural tissue characteristics. Furthermore, SOD and GPx activities were measured before ischemia and at the end of the reperfusion period. Results suggest that: (a) the activity of antioxidant enzymes increased or decreased significantly when diet was respectively supplemented with, or deficient in, trace elements, but was not further modified by an ischemia-reperfusion episode: (b) the recovery of cardiac function during reperfusion, and ventricular myocardial ultrastructure were significantly improved under the influence of trace element supplementation when compared to both standard and deficient groups. These results illustrate the protective effect of trace elements which are co-factors of antioxidant enzymes in limiting ischemia-reperfusion induced injury, and suggest a possible use in the field of anti-ischemic therapy.
S Pucheu; C Coudray; N Tresallet; A Favier; J de Leiris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  27     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-13     Completed Date:  1996-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2303-14     Citation Subset:  IM    
Groupe de Physiopathologie Cellulaire Cardiaque, URA CNRS 1287, Université Joseph Fourier, Grenoble, France.
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MeSH Terms
Administration, Oral
Antioxidants / administration & dosage,  therapeutic use*
Copper / administration & dosage,  deficiency,  therapeutic use
Glutathione Peroxidase / metabolism*
Heart / drug effects*
Heart Ventricles / chemistry,  ultrastructure
Manganese / administration & dosage,  deficiency,  therapeutic use
Myocardial Ischemia / drug therapy*,  metabolism,  pathology
Myocardial Reperfusion Injury / metabolism,  pathology,  prevention & control*
Myocardium / enzymology*,  pathology
Oxidative Stress
Rats, Wistar
Reactive Oxygen Species / metabolism
Selenium / administration & dosage,  deficiency,  therapeutic use
Superoxide Dismutase / metabolism*
Trace Elements / administration & dosage,  deficiency,  therapeutic use*
Zinc / administration & dosage,  deficiency,  therapeutic use
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 0/Trace Elements; 7439-96-5/Manganese; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium; EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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