| Effect of dietary antioxidant trace element supply on cardiac tolerance to ischemia-reperfusion in the rat. | |
| | |
MedLine Citation:
|
PMID: 8576945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Over a 10-week period, female Wistar rats received a diet containing various levels of four trace elements (Zn, Cu, Mn, Se), co-factors of antioxidant enzymes (superoxide dismutase SOD, glutathione peroxidase GPx), in order to examine the influence of supplementation or deficiency of these elements (i) on tissue antioxidant enzyme defence systems, and (ii) on the susceptibility of the myocardium to ischemia-reperfusion injury. At the end of the dietary treatment, hearts were perfused at constant flow (11 ml/min) before being subjected to 15 min of total global normothermic ischemia, followed by reperfusion. The effects of the various diets (deficient, standard or supplemented) were estimated by studying functional recovery of various cardiac parameters (left ventricular developed pressure LVDP, dP/dtmax, heart rate x LVDP) as well as ultrastructural tissue characteristics. Furthermore, SOD and GPx activities were measured before ischemia and at the end of the reperfusion period. Results suggest that: (a) the activity of antioxidant enzymes increased or decreased significantly when diet was respectively supplemented with, or deficient in, trace elements, but was not further modified by an ischemia-reperfusion episode: (b) the recovery of cardiac function during reperfusion, and ventricular myocardial ultrastructure were significantly improved under the influence of trace element supplementation when compared to both standard and deficient groups. These results illustrate the protective effect of trace elements which are co-factors of antioxidant enzymes in limiting ischemia-reperfusion induced injury, and suggest a possible use in the field of anti-ischemic therapy. |
| | |
Authors:
|
S Pucheu; C Coudray; N Tresallet; A Favier; J de Leiris |
Related Documents
:
|
1902295 - Dietary magnesium depletion: p-nitroanisole metabolism and glucuronidation in rat hepat... 9587135 - Essentiality of copper in humans. 8424155 - Zinc, copper, and selenium in milk and organs of cow and goat from burundi, africa. 7317345 - The effect of low dietary manganese intake on rainbow trout (salmo gairdneri). 6410365 - Effect of added methionine and lysine on the performance of chicks fed different alfalf... 6822895 - A metabolic comparison of cysteine and methionine supplements in the diet of a rat. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of molecular and cellular cardiology Volume: 27 ISSN: 0022-2828 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 1995 Oct |
Date Detail:
|
Created Date: 1996-03-13 Completed Date: 1996-03-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 2303-14 Citation Subset: IM |
Affiliation:
|
Groupe de Physiopathologie Cellulaire Cardiaque, URA CNRS 1287, Université Joseph Fourier, Grenoble, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Antioxidants / administration & dosage, therapeutic use* Copper / administration & dosage, deficiency, therapeutic use Diet Female Glutathione Peroxidase / metabolism* Heart / drug effects* Heart Ventricles / chemistry, ultrastructure Manganese / administration & dosage, deficiency, therapeutic use Myocardial Ischemia / drug therapy*, metabolism, pathology Myocardial Reperfusion Injury / metabolism, pathology, prevention & control* Myocardium / enzymology*, pathology Oxidative Stress Rats Rats, Wistar Reactive Oxygen Species / metabolism Selenium / administration & dosage, deficiency, therapeutic use Superoxide Dismutase / metabolism* Trace Elements / administration & dosage, deficiency, therapeutic use* Zinc / administration & dosage, deficiency, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Reactive Oxygen Species; 0/Trace Elements; 7439-96-5/Manganese; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human va...
Next Document: Adrenergic desensitization in left ventricle from streptozotocin diabetic swine.