Document Detail

Effect of dietary anion composition on acid-induced hypercalciuria in the adult rat.
MedLine Citation:
PMID:  3950765     Owner:  NLM     Status:  MEDLINE    
The effects of replacing dietary carbonate (0.3 meq/g diet) by sulfate (SO4) or chloride (Cl) on urinary calcium (Ca) excretion were investigated in the adult male rat. When anion substitutions were made by manipulating Ca and Mg salts, urinary Ca excretion was significantly higher in the SO4 and Cl groups, the Cl-induced calciuria being twice that of the SO4 group. Replacement of carbonate by chloride was associated with higher net acid excretion. Replacement by SO4 promoted an equivalent excretion of acid, if apparent absorption of anion is taken into account. When substitutions were made by manipulating magnesium, sodium and potassium but not Ca salts, urinary Ca excretion and net acid excretion were higher in both fixed anion groups. In this second study, absorption of anion in the Cl and SO4 groups was not different (54 and 59%, respectively). Feeding either Cl or SO4 raises urinary Ca to a similar extent when equivalent changes in acid-base balance are induced. The excessive calciuria, ascribed by others to the formation of CaSO4 complexes in the urine, is not manifest when net acid excretion is significantly increased.
S J Whiting; D E Cole
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  116     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-10     Completed Date:  1986-04-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  388-94     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects
Calcium / urine*
Carbonates / pharmacology,  urine
Chlorides / adverse effects*,  urine
Food, Formulated
Hydrogen-Ion Concentration
Nutritional Physiological Phenomena
Rats, Inbred Strains
Sodium / urine
Sulfates / adverse effects*,  urine
Reg. No./Substance:
0/Carbonates; 0/Chlorides; 0/Sulfates; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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