Document Detail


Effect of dietary alpha-linolenic acid on vascular reactivity in aorta of spontaneously hypertensive rats.
MedLine Citation:
PMID:  19367077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several studies of hypertension have shown that dietary alpha-linolenic acid (ALA) has a blood pressure-lowering effect. In the present study, we investigated the effect of dietary ALA on endothelium-dependent vascular reactivity in six-week-old spontaneously hypertensive rats (SHR). At the end of the feeding period, systolic blood pressure in the ALA group was significantly lower than in the control group. There was no significant difference in endothelium-dependent vasorelaxant response between the two diet groups. There was also no significant inter-group difference in the vascular wall thickness and media-to-lumen ratio. In conclusion, the present findings suggest that the blood pressure-lowering mechanism of dietary ALA does not involve increased sensitivity to NO or a change the in vascular morphology of the aorta.
Authors:
Akiko Ogawa; Yo Suzuki; Toshiaki Aoyama; Hiroyuki Takeuchi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of oleo science     Volume:  58     ISSN:  1347-3352     ISO Abbreviation:  J Oleo Sci     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-15     Completed Date:  2009-07-20     Revised Date:  2009-08-11    
Medline Journal Info:
Nlm Unique ID:  101175339     Medline TA:  J Oleo Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
Affiliation:
Central Research Laboratory, The Nisshin OilliO Group, Ltd., Kanagawa, Japan. a-ogawa@nisshin-oillio.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / drug effects*
Blood Pressure / drug effects*
Diet*
Disease Models, Animal
Eating / drug effects
Endothelium, Vascular / drug effects*,  physiology*
Male
Rats
Rats, Inbred SHR
alpha-Linolenic Acid / pharmacology*
Chemical
Reg. No./Substance:
463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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