Document Detail

Effect of dietary alpha-linolenate/linoleate balance on mean survival time, incidence of stroke and blood pressure of spontaneously hypertensive rats.
MedLine Citation:
PMID:  2905408     Owner:  NLM     Status:  MEDLINE    
Following the suckling period, stroke-prone spontaneously hypertensive rats (SHR-SP) were fed semi-purified diets supplemented either with safflower seed oil (rich in linoleic acid) or with perilla seed oil (rich in alpha-linolenic acid). The mean survival time of male SHR-SP fed the perilla diet was longer than that fed the safflower diet by 17% (p less than 0.001) while the difference was 15% in female SHR-SP (p less than 0.05). The mean survival times of female SHR-SP were more than 40% longer than those of male SHR-SP in both dietary groups. Post-mortem examinations of brains revealed apoplexy-related symptoms as the major cause of the death in both dietary groups. The systolic blood pressure was lower by ca. 10% (21 mmHg) in the perilla group than in both the safflower group and conventional diet group. The eicosapentaenoate (20:5 n-3)/arachidonate (20:4 n-6) ratio of platelet phospholipids in spontaneously hypertensive rat (SHR), a measure of platelet aggregability, was much higher in the perilla group than in the safflower group. Thus, increasing the dietary alpha-linolenate/linoleate ratio resulted in an increased mean survival time of SHR-SP rats, possibly by lowering blood pressure and platelet aggregability.
T Shimokawa; A Moriuchi; T Hori; M Saito; Y Naito; H Kabasawa; Y Nagae; M Matsubara; H Okuyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  43     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-16     Completed Date:  1989-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2067-75     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
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MeSH Terms
Blood Pressure / drug effects*
Cerebrovascular Disorders / physiopathology*,  prevention & control
Dietary Fats / pharmacology*
Linoleic Acid
Linoleic Acids / pharmacology*
Linolenic Acids / pharmacology*
Longevity / drug effects*
Plant Oils / pharmacology*
Platelet Aggregation / drug effects
Rats, Inbred SHR
Rats, Inbred WKY
Reference Values
Safflower Oil / pharmacology*
Sex Factors
alpha-Linolenic Acid
Reg. No./Substance:
0/Dietary Fats; 0/Linoleic Acids; 0/Linolenic Acids; 0/Plant Oils; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid; 68132-21-8/perilla seed oil; 8001-23-8/Safflower Oil

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