Document Detail

Effect of diet and weight reduction in hypertension.
MedLine Citation:
PMID:  2134545     Owner:  NLM     Status:  MEDLINE    
Weight reduction by a low-energy diet and a high-polyunsaturates-, fiber- and potassium-rich diet may be independently useful to hypertensives. To study the effect of such diets, 416 hypertensives were randomized to either a low-energy cardiovasoprotective (CVP) diet (Group A; n = 106), a low-energy usual diet (Group B; n = 104), an optimal-energy CVP diet (Group C; n = 104), or an optimal-energy, usual pre-experimental diet (Group D; n = 102) plus drug therapy in a single-blind and controlled fashion. Groups A and B received significant (p less than 0.02) fewer calories per day than Groups C and D. Groups A and C also received significantly (p less than 0.02) more calories per amount of complex carbohydrates, polyunsaturates, potassium, and magnesium than did Groups B and D. Dietary compliance and drug intake was checked weekly. After 3 months, there was a significant fall in mean serum cholesterol (p less than 0.01) and mean serum triglycerides (p less than 0.05) in Group A compared with Group D. Group A and B patients had a loss of around 10kg of mean body weight, with no weight change seen in Group D. Weight loss was associated with a significant fall in systolic and diastolic pressures in both Group A (22/18mmHg) and Group B (16/13mmHg) compared with Group D at the end of the study. Group C patients also showed a significant fall in pressure (13/10mmHg) compared with Group D. Drug therapy, exercise, and salt intake were similar in all the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
R B Singh; S S Rastogi; P J Mehta; R Mody; V Garg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  6     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    1990 Jul-Aug
Date Detail:
Created Date:  1992-04-30     Completed Date:  1992-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  IM    
Medical Hospital and Research Centre, Moradabad, India.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Combined Modality Therapy
Diet, Reducing
Hypertension / diet therapy*,  drug therapy,  physiopathology
Middle Aged
Weight Loss
Reg. No./Substance:
0/Antihypertensive Agents

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