Document Detail


Effect of diet on the single- and multiple-dose pharmacokinetics of sustained-release ketoprofen.
MedLine Citation:
PMID:  7875189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The indirect effect of diet on the single- and multiple-dose pharmacokinetics of sustained-release ketoprofen was studied in 16 healthy male volunteers. In an open, cross-over design, 200 mg ketoprofen was administered as a gastric-juice-resistant, sustained-release tablet once daily during two periods of 5 days. A low-calorie/low-fat diet (LCFD) was given in the first period and a high-calorie/high-fat diet (HCFD) in the second period. The first meal on each day was given 4 h after drug intake. Ketoprofen plasma concentrations were measured over 24 h after the first dose on day 1 and over 36 h after the final dose on day 5 of each period. On average, plasma concentrations of ketoprofen were higher with the LCFD than with the HCFD. With the HCFD there was a tendency to longer absorption-lag times on day 5. The maximum concentration and the area under the curve over one 24-h dosage period (AUC0-24) were significantly higher with the LCFD, both on day 1 and on day 5. For AUC0-24 the differences were on average 15% (day 1) and 24% (day 5). The same tendency was observed for the amount excreted in urine over 24 h (Ae), but the difference was only significant on day 1 (14%). The elimination rate constant (K beta) and the mean residence time were similar for the two diets, both on day 1 and on day 5. From these results, we conclude that there was an acute indirect effect of diet when a meal was had 4 h after intake of the medication.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
A Le Liboux; M Teule; A Frydman; B Oosterhuis; J H Jonkman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  47     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1994  
Date Detail:
Created Date:  1995-04-06     Completed Date:  1995-04-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  361-6     Citation Subset:  IM    
Affiliation:
Rhône-Poulenc Rorer, Institute of Biopharmacy, Antony, France.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Biological Availability
Delayed-Action Preparations
Diet*
Eating
Humans
Ketoprofen / pharmacokinetics*
Male
Urine
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 22071-15-4/Ketoprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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