| Effect of diet hardness on mandibular condylar cartilage metabolism. | |
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MedLine Citation:
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PMID: 21359239 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aims: To study the effect of diet hardness on condylar cartilage thickness, extracellular matrix composition, and expression of matrix metalloproteinase (MMP) -3, -8 and tissue inhibitor of metalloproteinase-1 (TIMP-1), by using immunohistochemical and morphometric methods. Methods: Seventy-two female Sprague Dawley rats were exposed to different dietary hardness, from soft to hard. MMP -3, -8, and TIMP-1 expression, cartilage thickness, cell count, and expression of type II collagen were studied. Analysis of variance among treatments was carried out followed by Bonferroni's comparisons test. Results: The ratio of MMP-3 and TIMP-1 immunopositive cartilage cells were similar in all age groups, whereas the number of MMP-8 positive cells decreased with age. A change of diet from soft to hard caused a significant decrease in the number of MMP-3 and MMP-8 and an increase in TIMP-1 positive cells. Cartilage thickness and area of type II collagen-positive staining were significantly affected by diet hardness. Conclusion: The results show that a soft diet during growth increases collagenolytic activity and may increase the vulnerability of condylar cartilage. J OROFAC PAIN 2011;25:68-74. |
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Authors:
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Petri Tiilikainen; Aune Raustia; Pertti Pirttiniemi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of orofacial pain Volume: 25 ISSN: 1064-6655 ISO Abbreviation: J Orofac Pain Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9418507 Medline TA: J Orofac Pain Country: United States |
Other Details:
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Languages: eng Pagination: 68-74 Citation Subset: D |
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