Document Detail

Effect of diet and L-thyroxine on deiodination of L-thyroxine in rat liver
MedLine Citation:
PMID:  516998     Owner:  NLM     Status:  MEDLINE    
Male Wistar rats on 3 or 50% fat diet for 14 weeks were treated during 6 weeks with L-thyroxine (5 or 25 or 50 microgram 100 g body weight/2 times weekly, sc.) and the activity of L-thyroxine-deiodinase was determined in supernatans of liver homogenates. With increasing thyroxine lading the deiodinating activity increases statistically significantly within each diet group. The liver of animals on 50% fat diet deiodinates increasing thyroxine doses to a lesser extent than livers of animals on 3% fat diet. It is discussed that high fat diet influences thyroid function and that thyroxine shares effectiveness and undergoes deiodination also in other tissues, probably in fat tissue, to a higher extent.
C Voss; N Hartmann
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Acta biologica et medica Germanica     Volume:  38     ISSN:  0001-5318     ISO Abbreviation:  Acta Biol. Med. Ger.     Publication Date:  1979  
Date Detail:
Created Date:  1980-02-15     Completed Date:  1980-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370276     Medline TA:  Acta Biol Med Ger     Country:  GERMANY, EAST    
Other Details:
Languages:  ger     Pagination:  65-8     Citation Subset:  IM    
Vernacular Title:
Zum Einfluss von Diät und L-Thyroxin auf die Dejodierung von L-Thyroxin in der Leber von Ratten.
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MeSH Terms
Dietary Fats*
Iodide Peroxidase / metabolism*
Liver / drug effects,  metabolism*
Peroxidases / metabolism*
Thyroxine / metabolism*,  pharmacology
Reg. No./Substance:
0/Dietary Fats; 7488-70-2/Thyroxine; EC 1.11.1.-/Peroxidases; EC Peroxidase

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