| Effect of dichloromethylene diphosphonate (Cl2-MDP) on bone resorption induced by PHA-stimulated human mononuclear cells in organ culture. | |
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MedLine Citation:
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PMID: 6236769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human mononuclear cells stimulated by PHA caused resorption of fetal rat bones in tissue culture. Non-adherent cells alone failed to produce substantial bone resorbing activity. The mixed culture of adherent and non-adherent cells (1:40) produced significant bone mineral resorption in vitro. The bone resorption induced by human mononuclear cells stimulated by PHA required the presence of living bone tissue in culture. The bone resorbing effect caused by PHA-stimulated cells was blocked by dichloromethylene diphosphonate at 10(-5) M concentration, but mononuclear cells preincubated in diphosphonate containing media were capable to resorb fetal rat bone in tissue culture. |
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Authors:
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H M Holak; S Szymaniec; A Skriabin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archivum immunologiae et therapiae experimentalis Volume: 32 ISSN: 0004-069X ISO Abbreviation: Arch. Immunol. Ther. Exp. (Warsz.) Publication Date: 1984 |
Date Detail:
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Created Date: 1984-10-12 Completed Date: 1984-10-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0114365 Medline TA: Arch Immunol Ther Exp (Warsz) Country: POLAND |
Other Details:
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Languages: eng Pagination: 77-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Resorption / drug effects* Cell Adhesion Clodronic Acid / pharmacology* Diphosphonates / pharmacology* Humans Leukocytes / immunology* Lymphocyte Activation Lymphokines / biosynthesis Organ Culture Techniques Phytohemagglutinins / pharmacology Rats |
| Chemical | |
Reg. No./Substance:
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0/Diphosphonates; 0/Lymphokines; 0/Phytohemagglutinins; 10596-23-3/Clodronic Acid; 64060-24-8/osteoclast activating factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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