Document Detail

Effect of the diazepam-binding inhibitor-derived peptide, octadecaneuropeptide, on food intake in goldfish.
MedLine Citation:
PMID:  17936516     Owner:  NLM     Status:  MEDLINE    
An endogenous ligand of central-type benzodiazepine receptors (CBR), the endozepine octadecaneuropeptide (ODN), is a very potent inhibitor of food intake in rodents. Although endozepines have been localized and characterized in the trout hypothalamus, so far, the action of these neuropeptides on feeding behavior has never been investigated in fish. In the present study, we have examined the effect of i.c.v. administration of synthetic rat ODN, its C-terminal octapeptide (OP) and the head-to-tail cyclic analog cyclo(1-8)OP (cOP) on feeding behavior in the goldfish model. i.c.v. injection of graded doses of ODN (2.5-10 pmol/g body weight (BW)) induced a dose-dependent inhibition of food intake, a significant decrease in cumulative food intake during the 60-min period after feeding being observed at doses of 5 and 10 pmol/g BW. The inhibitory effect of a 10 pmol/g BW dose of ODN on food consumption (-39%) was mimicked by an equimolar dose of OP (-42%) and cOP (-53%). The food intake-suppressing activity of ODN (10 pmol/g BW) was not affected by pre-injection of the CBR antagonist flumazenil (200 pmol/g BW). In contrast, the anorexigenic effect of ODN (10 pmol/g BW) was totally suppressed by a selective antagonist of metabotropic endozepine receptors, cyclo(1-8)[dLeu(5)]OP. These data indicate that, in goldfish as in rodents, ODN is a potent inhibitor of food consumption, and that the anorexigenic effect of ODN is not mediated through CBR but through the metabotropic endozepine receptor.
K Matsuda; K Wada; T Miura; K Maruyama; S I Shimakura; M Uchiyama; J Leprince; M C Tonon; H Vaudry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-14
Journal Detail:
Title:  Neuroscience     Volume:  150     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-32     Citation Subset:  IM    
Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, 3190-Gofuku, Toyama 930-8555, Japan.
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MeSH Terms
Appetite Regulation / drug effects*,  physiology
Brain / drug effects*,  metabolism
Diazepam Binding Inhibitor / chemistry,  pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects,  physiology
Feeding Behavior / drug effects,  physiology
Flumazenil / pharmacology
GABA Modulators / pharmacology
Neuropeptides / chemistry,  pharmacology*
Peptide Fragments / chemistry,  pharmacology*
Receptors, GABA-A / drug effects*,  metabolism
Reg. No./Substance:
0/Diazepam Binding Inhibitor; 0/GABA Modulators; 0/Ligands; 0/Neuropeptides; 0/Peptide Fragments; 0/Receptors, GABA-A; 0/diazepam binding inhibitor (33-50); 78755-81-4/Flumazenil

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