Document Detail

Effect of diazepam binding inhibitor (DBI) on the fluid intake, preference and the taste reactivity in mice.
MedLine Citation:
PMID:  11704264     Owner:  NLM     Status:  MEDLINE    
We have reported that a diazepam binding inhibitor (DBI)-like peptide is released by the aversive quinine stimuli 'Chem. Senses 25 (2000) 739'. To determine the effect of DBI on the fluid intake, we injected a DBI peptide fragment into the fourth ventricle in mice. DBI suppressed the intake of 5% sucrose, water and 0.9 mM quinine-HCl and the preference for 0.05% saccharin. Administration (i.p.) of flumazenil, a benzodiazepine receptor antagonist, 20 min before the injection of DBI (i.c.v.) antagonized the suppressive effect of DBI on the intake and the preference for saccharin. We also studied the dose dependency of the effect of DBI on the intake of 5% sucrose. Injection of DBI in excess of 3 microg suppressed the intake of 5% sucrose in mice. Furthermore, injection of DBI (i.c.v.) increased the aversive response to 0.9% NaCl in the taste reactivity in mice. These results suggest that DBI affect the preference to food.
Y Manabe; T Toyoda; K Kuroda; M Imaizumi; T Yamamoto; T Fushiki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioural brain research     Volume:  126     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2002-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  IM    
Laboratory of Nutrition Chemistry, Division of Applied Life Science, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Kyoto 606-8502, Japan.
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MeSH Terms
Avoidance Learning / drug effects
Brain / drug effects
Choice Behavior / drug effects*
Dose-Response Relationship, Drug
Drinking / drug effects*
Flumazenil / pharmacology
Injections, Intraventricular
Mice, Inbred Strains
Neuropeptides / pharmacology*
Peptide Fragments / pharmacology*
Taste / drug effects*
Reg. No./Substance:
0/Neuropeptides; 0/Peptide Fragments; 0/diazepam-binding inhibitor (51-70); 78755-81-4/Flumazenil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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