Document Detail

Effect of diamide on proton translocation by the mitochondrial H+-ATPase.
MedLine Citation:
PMID:  2866768     Owner:  NLM     Status:  MEDLINE    
Treatment of sonic submitochondrial particles with the bifunctional thiol reagent, diamide, results in an enhancement of proton conductivity and ATPase activity, which is reversed by the reducing agent dithiothreitol, is suppressed by Fo inhibitors like oligomycin and is absent in particles that are deprived of peripheral Fo polypeptides. The effect of diamide is apparently due to oxidation of dithiols to disulfides in peripheral polypeptide(s) of Fo.
F Zanotti; F Guerrieri; R Scarfò; J Berden; S Papa
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  132     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1986-01-08     Completed Date:  1986-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  985-90     Citation Subset:  IM    
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MeSH Terms
Azo Compounds / pharmacology*
Biological Transport
Diamide / pharmacology*
Dicyclohexylcarbodiimide / pharmacology
Dithiothreitol / pharmacology
Mitochondria / enzymology*
Potassium / metabolism
Proton-Translocating ATPases / physiology*
Reg. No./Substance:
0/Azo Compounds; 0/Protons; 10465-78-8/Diamide; 3483-12-3/Dithiothreitol; 538-75-0/Dicyclohexylcarbodiimide; 7440-09-7/Potassium; EC ATPases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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