Document Detail

Effect of diabetes mellitus on muscle size and strength in patients receiving dialysis therapy.
MedLine Citation:
PMID:  16632026     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Diabetes mellitus (DM) is a potential contributor to the muscle abnormalities and poor physical functioning of the dialysis population. METHODS: Thirty-three dialysis patients without DM (non-DM group) were compared with 25 dialysis patients with DM (DM group). Measures were made of cross-sectional area and composition of the leg muscles by using proton T1-weighted magnetic resonance imaging; body composition by means of dual-energy X-ray absorptiometry; leg muscle strength by means of isokinetic knee extension; isometric dorsiflexor maximum voluntary contraction by means of force plate; physical activity by means of 3-dimensional accelerometry; and functional capacity by using various functional tests. RESULTS: The DM group was older, weaker, more atrophic, and had a greater amount of intramuscular fat compared with the non-DM group. However, when the overall analysis was adjusted for age and sex, there were no differences between the 2 groups with respect to muscle cross-sectional area, leg strength, or physical activity. To further account for sex and age differences, a paired analysis was performed after matching patients by age (within 5 years) and sex (N = 16/group). In the matched analysis, only intramuscular fat and leg adipose tissue were different between the 2 groups. CONCLUSION: DM is associated with more fat within muscles of dialysis patients, but is unrelated to muscle size or strength. Demographic differences between the DM and non-DM groups on dialysis therapy likely are responsible for the general perception that patients with DM are more debilitated.
Giorgos K Sakkas; Jane A Kent-Braun; Julie W Doyle; Tiffany Shubert; Patricia Gordon; Kirsten L Johansen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  47     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-24     Completed Date:  2006-06-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  862-9     Citation Subset:  IM    
General Clinical Research Center, San Francisco General Hospital, USA.
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MeSH Terms
Diabetes Complications / complications,  pathology*,  physiopathology*
Kidney Failure, Chronic / complications*,  therapy*
Middle Aged
Muscle, Skeletal / pathology*,  physiopathology*
Muscular Atrophy / complications,  pathology*,  physiopathology*
Organ Size
Renal Dialysis*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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