| Effect of diabetes and hypertension on left ventricular diastolic function in a high-risk population without evidence of heart disease. | |
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MedLine Citation:
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PMID: 20211851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To assess the independent and combined effects of diabetes and hypertension on left ventricular (LV) diastolic function in a community-based cohort at high cardiovascular risk. METHODS AND RESULTS: Two-dimensional echocardiography was performed in 708 subjects from the Cardiac Abnormalities and Brain Lesions (CABL) study. Peak diastolic early (E) and late (A) transmitral flow, and tissue Doppler-derived early mitral annulus velocity (E') were recorded, and E/A and E/E' ratios were calculated. The population was divided into four groups: those without hypertension or diabetes (HT-/DM-), those with only hypertension (HT), only diabetes (DM), and with hypertension plus diabetes (HT + DM). In multivariate analysis, hypertension and diabetes were independent predictors of worse diastolic function. The coexistence of hypertension and diabetes was associated with greater impairment of diastolic function (higher E/E' ratio than HT-/DM-, HT, or DM, all P < 0.05), independent of covariates. The negative, synergistic effect of hypertension and diabetes on LV diastolic function was present both in lean participants and in overweight/obese ones. An E/E' ratio >15, suggestive of increased LV filling pressure, was found in 2.2% of HT-/DM-, 8.9% of HT, 5.9% of DM, and 14.7% of HT + DM (P < 0.01). CONCLUSION: Hypertension and diabetes are independently associated with impaired LV diastolic function, independent of the effect of overweight/obesity and other covariates. Their coexistence results in a negative synergistic effect on LV diastolic mechanics and is associated with higher LV filling pressures than either condition alone. |
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Authors:
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Cesare Russo; Zhezhen Jin; Shunichi Homma; Tatjana Rundek; Mitchell S V Elkind; Ralph L Sacco; Marco R Di Tullio |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-03-07 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2011-06-02 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 454-61 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH3-342 630 West 168th Street, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Confidence Intervals Diabetes Mellitus / physiopathology*, ultrasonography Diastole Female Humans Hypertension / complications*, ultrasonography Incidence Linear Models Male Multivariate Analysis New York City / epidemiology Prevalence Risk Assessment Risk Factors Statistics as Topic Statistics, Nonparametric Ventricular Dysfunction, Left / epidemiology, ultrasonography* Ventricular Function, Left* |
| Grant Support | |
ID/Acronym/Agency:
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NS29993/NS/NINDS NIH HHS; R01 NS36286/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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