| Effect of dextran and enoxaparin on early ePTFE graft thrombogenicity in sheep. | |
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MedLine Citation:
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PMID: 7542544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the effect of low molecular weight heparin (LMWH), dextran 70 and their combination on platelet adhesion and fibrinogen uptake in ePTFE grafts in an experimental sheep model. DESIGN: Prospective open study. SETTING: Animal Laboratory of a University Hospital. MATERIALS: Early thrombogenicity of ePTFE grafts was studied after interposition in the two common carotid arteries of 40 adult sheep. The animals received one of four different treatment regimens in a double blind randomised way: enoxaparin and polygeline, saline and dextran 70, enoxaparin and dextran 70 or saline and polygeline (control). The substances were administered i.v. with a total dose of 73 antifactor-Xa U/kg for enoxaparin and 1.0 g/kg for dextran 70. Polygeline and saline were used as placebo substances in equivalent volumes. On one side (random allocation) the carotid blood flow was restricted to 25 ml/min, on the other side it was left unrestricted. CHIEF OUTCOME MEASURES: The following variables were studied: 1) fibrinogen uptake; 2) platelet uptake; 3) early graft patency; 4) blood flow in patient grafts; 5) visible presence of graft thrombus; 6) thrombus weight. MAIN RESULTS: The results verified the importance of adequate blood flow as only 30% of grafts with restricted blood flow in the control group were patent compared with 80% of those with unrestricted blood flow (p = 0.038). Dextran 70, enoxaparin and the combination of the two increased early graft patency (p < 0.05) and reduced thrombus weights (p < 0.05) in grafts with restricted blood flow. The relative number of grafts with thrombus free surface was increased in the unrestricted blood flow situation. CONCLUSIONS: Dextran 70 and enoxaparin appeared to be equally effective in decreasing fibrinogen and platelet uptake in the grafts. Their combination was not significantly more effective although there was a favourable trend. |
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Authors:
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S E Matthiasson; D Bergqvist; A Lundell; B Lindblad |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 9 ISSN: 1078-5884 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-08-31 Completed Date: 1995-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 284-92 Citation Subset: IM |
Affiliation:
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Department of Surgery, Lund University, University Hospital MAS, Malmö, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessel Prosthesis* Carotid Artery, Common / surgery Dextrans / administration & dosage, pharmacology* Double-Blind Method Drug Therapy, Combination Enoxaparin / administration & dosage, pharmacology* Female Fibrinogen / metabolism Graft Occlusion, Vascular / prevention & control*, radionuclide imaging Male Platelet Adhesiveness / drug effects Polygeline / administration & dosage, pharmacology Polytetrafluoroethylene* Random Allocation Sheep Sodium Chloride / administration & dosage, pharmacology Thrombosis / prevention & control*, radionuclide imaging Vascular Patency / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Enoxaparin; 7647-14-5/Sodium Chloride; 9001-32-5/Fibrinogen; 9002-84-0/Polytetrafluoroethylene; 9004-54-0/Dextrans; 9015-56-9/Polygeline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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