| Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study. | |
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MedLine Citation:
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PMID: 20124943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To characterize the effects of dexmedetomidine on the pulmonary artery pressure in patients after congenital cardiac surgery. DESIGN: Prospective observational pilot study. SETTING: Pediatric cardiac intensive care unit at a university hospital. PATIENTS: Twenty-two patients who received dexmedetomidine after cardiothoracic surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: An echocardiogram was performed at three time points: 1) baseline (T0); 2) 6 mins after dexmedetomidine loading (T1); and 3) 1 hr after initiation of dexmedetomidine infusion (T2). Transthoracic echocardiography was used to estimate pulmonary artery pressure based on tricuspid regurgitant velocity (4 x Velocity2) plus central venous pressure. Twenty-two patients aged 0.9 yrs old (interquartile range, 7.9) were enrolled at a median of 1 hr (1.5) after surgery. Dexmedetomidine loading, 0.62 microg/kg (0.5), was given in all patients followed by 0.5 microg/kg/hr (0.6) at T1 and 0.65 microg/kg/hr (0.5) at T2. None of the patients had any increase in pulmonary artery pressure. Overall, the pulmonary artery pressure decreased from 30 mm Hg (13) at T0 to 24 mm Hg (10) at T1 and 26 mm Hg (8) at T2 (p < .001). The pulmonary artery pressure/systemic systolic blood pressure ratio decreased from 33% (12) at T0 to 23% (15) at T1 and 25% (13) at T2 (p = .002). There was no difference in the left ventricular function, Fio2, oxygen %, Po2, CO2, and vasoactive agents. CONCLUSIONS: Administration of dexmedetomidine after congenital cardiac surgery was not associated with any increase in pulmonary artery pressure. |
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Authors:
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Judith P Lazol; Steven E Lichtenstein; Edmund H Jooste; Dana Shiderly; Nivedit A Kudchadker; Gregory H Tatum; Richard A Orr; Peter D Wearden; Victor O Morell; Ricardo A Munoz; Constantinos Chrysostomou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Volume: 11 ISSN: 1529-7535 ISO Abbreviation: Pediatr Crit Care Med Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954653 Medline TA: Pediatr Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 589-92 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-2 Receptor Agonists
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pharmacology*,
therapeutic use Blood Pressure / drug effects* Child Child, Preschool Dexmedetomidine / pharmacology*, therapeutic use Echocardiography Female Heart Defects, Congenital / surgery* Humans Hypnotics and Sedatives / pharmacology*, therapeutic use Infant Male Pilot Projects Prospective Studies Pulmonary Artery / drug effects*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-2 Receptor Agonists; 0/Hypnotics and Sedatives; 113775-47-6/Dexmedetomidine |
| Comments/Corrections | |
Comment In:
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Pediatr Crit Care Med. 2010 Sep;11(5):634-5
[PMID:
20823739
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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