Document Detail

Effect of dexmedetomidine on bleeding during tympanoplasty or septorhinoplasty.
MedLine Citation:
PMID:  17241505     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: The aim of this study was to evaluate the efficacy of dexmedetomidine, an alpha(2)-adrenoceptor agonist, on intraoperative bleeding, anaesthetic drug requirement and postoperative pain. METHODS: Forty patients scheduled for elective tympanoplasty and septorhinoplasty operations under general anaesthesia were included in the study. The patients were randomly assigned to receive either a dexmedetomidine 1 microg kg(-1) bolus 10 min before induction of anaesthesia plus 0.5 microg kg(-1) h(-1) infusions during maintenance or placebo. Mean arterial pressure was maintained between 60 and 80 mmHg. Perioperative mean arterial pressure, heart rate, time to extubation and time to awakening were recorded. Bleeding during surgery was assessed by the surgeon, blinded to the study drugs, both intraoperatively and postoperatively as a final personal opinion about the whole surgical process. RESULTS: The heart rate and mean arterial pressure were significantly lower during induction, operation and extubation in the dexmedetomidine group (P < 0.05). Blood losses were lower in the dexmedetomidine group (P < 0.05). Propofol dose required for induction, and fentanyl and isoflurane consumption were significantly reduced in the dexmedetomidine group (P < 0.05). The total amounts of nitroglycerin and meperidine used were higher in the control group (P < 0.05). CONCLUSIONS: Dexmedetomidine decreased bleeding, postoperative analgesic requirements and intraoperative anaesthetic requirements and was associated with more stable haemodynamic responses to anaesthesia. We conclude that dexmedetomidine is a useful adjuvant to decrease bleeding when a bloodless surgical field is requested.
M Durmus; A K But; Z Dogan; A Yucel; M C Miman; M O Ersoy
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-01-23
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  24     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-18     Completed Date:  2007-07-26     Revised Date:  2008-01-23    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  447-53     Citation Subset:  IM    
Inonu University, School of Medicine, Department of Anaesthesiology, Malatya, Turkey.
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MeSH Terms
Adrenergic alpha-Agonists / therapeutic use*
Analgesics, Opioid / administration & dosage
Anesthesia, General
Anesthetics, Inhalation / administration & dosage
Anesthetics, Intravenous / administration & dosage
Blood Loss, Surgical / prevention & control*
Blood Pressure / drug effects
Dexmedetomidine / therapeutic use*
Double-Blind Method
Heart Rate / drug effects
Pain, Postoperative / prevention & control
Postoperative Hemorrhage / prevention & control
Prospective Studies
Surgical Procedures, Elective
Time Factors
Treatment Outcome
Vasodilator Agents / administration & dosage
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Analgesics, Opioid; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Vasodilator Agents; 113775-47-6/Dexmedetomidine
Comment In:
Eur J Anaesthesiol. 2007 Nov;24(11):985-6   [PMID:  18035604 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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